Phenotypes associated with this allele

• Allele Symbol: Ppif^tm1.1Mmos
• Allele Name: targeted mutation 1.1, Michael A Moskowitz
• Allele ID: MGI:3603458
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppif^tm1.1Mmos/Ppif^tm1.1Mmos	involves: 129X1/SvJ * FVB/NJ	MGI:3608595
ht2	Ppif^tm1.1Mmos/Ppif^+	involves: 129X1/SvJ * FVB/NJ	MGI:3608596

Genotype
MGI:3608595

hm1

• Allelic Composition: Ppif^tm1.1Mmos/Ppif^tm1.1Mmos
• Genetic Background: involves: 129X1/SvJ * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:101149 )

• cultured embryonic fibroblasts from homozygotes are less susceptible to H₂O₂ induced cell death but respond normally to etoposide, staurosporine, thapsigargin, tunicamycin, brefeldin A, tumor necrosis factor alpha and TNFSF10

• 100uM CaCl₂ fails to induce mitochondiral swelling in mitochondria from homozygous liver

nervous system

nervous system phenotype ( J:101149 )

N • normal brain and cerebrovasculature

decreased cerebral infarct size ( J:101149 )

• infarct volume induced by middle cerebral artery occlusion is reduced by 62% in homozygotes relative to wild-type siblings

homeostasis/metabolism

decreased cerebral infarct size ( J:101149 )

• infarct volume induced by middle cerebral artery occlusion is reduced by 62% in homozygotes relative to wild-type siblings

Genotype
MGI:3608596

ht2

• Allelic Composition: Ppif^tm1.1Mmos/Ppif⁺
• Genetic Background: involves: 129X1/SvJ * FVB/NJ

nervous system

decreased cerebral infarct size ( J:101149 )

• infarct volume induced by middle cerebral artery occlusion is reduced by 37% in heterozygotes relative to wild-type siblings

homeostasis/metabolism

decreased cerebral infarct size ( J:101149 )

• infarct volume induced by middle cerebral artery occlusion is reduced by 37% in heterozygotes relative to wild-type siblings