Ppif^tm1.1Mmos
Targeted Allele Detail

Summary

• Symbol: Ppif^tm1.1Mmos
• Name: peptidylprolyl isomerase F (cyclophilin F); targeted mutation 1.1, Michael A Moskowitz
• MGI ID: MGI:3603458
• Synonyms: CypD^null
• Gene: Ppif Location: Chr14:25694578-25700892 bp, + strand Genetic Position: Chr14, 15.06 cM
• Alliance: Ppif^tm1.1Mmos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101149
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to insert loxP sites around exons 3-5. Crossing with mice expressing cre in the germ line resulted in a null allele, as was demonstrated by immunoblot of liver samples. (J:101149)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppif Mutation: 18 strains or lines available

References

• Original: J:101149 Schinzel AC, et al., Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12005-10
• All: 16 reference(s)