Phenotypes associated with this allele
Allelic Composition |
Bace1tm1Psa/Bace1tm1Psa
|
|
Genetic Background |
either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * CD-1) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
|
|
|
mortality/aging
|
• 19% die within the first 3-6 days of birth and 24% die by 3-4 weeks of age
|
growth/size/body
|
• mice surviving to adulthood are about 30% smaller by weight than controls
|
|
• the 24% that die by 3-4 weeks of age die from a wasting syndrome, although overall immune defense is normal
|
|
• the 24% that die by 3-4 weeks of age are growth retarded
|
behavior/neurological
nervous system
|
• neurons do not process APP at the known beta-secretase sites and thus do not produce any measurable Abeta, although glial cells do produce Abeta
|
|
• significant shift in steady-state inactivation of the Na+ current toward more depolarized potentials, indicating that a larger fraction of Na+ channels is available at a given potential compared to wild-type
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
|
|
|
muscle
|
• small diameter and few intrafusal fibers
|
|
• in newborn mice persisting through adulthood
• however, muscle spindle number at P0 is normal
|
behavior/neurological
|
• mice hang on to an inverted grid 3 times less than wild-type mice
|
|
• impaired left/right coordination
• swaying walking
|
nervous system
|
• small diameter and few intrafusal fibers
|
|
• in newborn mice persisting through adulthood
• however, muscle spindle number at P0 is normal
|
|
• peripheral without Schwann cell turn-over
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
|
|
|
pigmentation
N |
• mice do not display any coat color defects on a C57BL/6J background
|
Allelic Composition |
Bace1tm1Psa/Bace1+
|
|
Genetic Background |
involves: 129S2/SvPas * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
|
|
|
muscle
|
• in newborn mice persisting through adulthood
|
nervous system
|
• in newborn mice persisting through adulthood
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
Bace2tm1Bdes mutation
(2 available);
any
Bace2 mutation
(41 available)
|
|
|
mortality/aging
|
• approximately 42% die within the first 3-5 days after birth and an additional 20% die within the first 3-4 weeks of age
|
growth/size/body
|
• mice surviving to adulthood are smaller than controls
|
|
• the 20% that die by 3-4 weeks of age die from a wasting syndrome
|
nervous system
|
• neurons and glia do not process APP and thus do not produce Abeta
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
Nrg1tm4.1Cbm mutation
(0 available);
any
Nrg1 mutation
(53 available)
|
|
|
muscle
|
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
|
|
• more pronounced in Nrg1tm4.1Cbm homozygotes
|
nervous system
|
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
|
|
• more pronounced in Nrg1tm4.1Cbm homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation
(0 available);
any
Bace1 mutation
(27 available)
Tg(Thy1-Nrg1*I)1Kan mutation
(0 available)
|
|
|
muscle
|
• as in Bace1tm1Psa homozygotes
|
nervous system
N |
• unlike Tg(Thy1-Nrg1*I)1Kan mice, there is no increase in the survival of proprioceptive neurons during the selection phase
|
|
• as in Bace1tm1Psa homozygotes
|