Bace2^tm1Bdes
Targeted Allele Detail

Summary

• Symbol: Bace2^tm1Bdes
• Name: beta-site APP-cleaving enzyme 2; targeted mutation 1, Bart De Strooper
• MGI ID: MGI:3603144
• Synonyms: BACE2delta6, Bace2^tm1Psa
• Gene: Bace2 Location: Chr16:97157942-97244136 bp, + strand Genetic Position: Chr16, 57.4 cM
• Alliance: Bace2^tm1Bdes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100925
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre mediated recombination was used to remove exon 6 from the locus. (J:100925)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bace2 Mutation: 41 strains or lines available

References

• Original: J:100925 Dominguez D, et al., Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806
• All: 10 reference(s)