Phenotypes associated with this allele

• Allele Symbol: Rr149356^tm1.1Pf
• Allele Name: targeted mutation 1.1, Pierre Ferrier
• Allele ID: MGI:3590151
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr149356^tm1.1Pf/Rr149356^tm1.1Pf	either: 129P2/OlaHsd-Rr149356^tm1.1Pf or (involves: 129P2/OlaHsd * BALB/c)	MGI:3590337

Genotype
MGI:3590337

hm1

• Allelic Composition: Rr149356^tm1.1Pf/Rr149356^tm1.1Pf
• Genetic Background: either: 129P2/OlaHsd-Rr149356^tm1.1Pf or (involves: 129P2/OlaHsd * BALB/c)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus morphology ( J:34311 )

abnormal thymus cortex morphology ( J:34311 )

• the cortex contains more densely packed cells but is otherwise normal

abnormal thymus medulla morphology ( J:34311 )

• the medulla is smaller and contains few compacted cells

decreased thymocyte number ( J:34311 )

• in 4 week old homozygotes the number of thymocytes is reduced from 7- to 60-fold compared to wild-type littermates

abnormal T cell differentiation ( J:34311 )

increased double-negative T cell number ( J:34311 )

• double negative and CD25+ cells are proportionally overrepresented

decreased double-positive T cell number ( J:34311 )

• double positive T cells are proportionally underrepresented

arrested T cell differentiation ( J:34311 )

• differentiation of alphabeta precursors beyond the CD25+ double negative stage is impaired and Tcrb gene rearrangement is absent

increased gamma-delta T cell number ( J:34311 )

• CD3epsilon+ gammadelta+ cells are proportionally overrepresented

decreased T cell number ( J:34311 )

• CD3epsilon+ alphabeta+ T cells are proportionally underrepresented

decreased single-positive T cell number ( J:34311 )

• single positive cells are proportionally underrepresented

lymph node hypoplasia ( J:34311 )

• the number of cells in the lymph nodes is decreased but to a lesser extent than in the thymus

hematopoietic system

abnormal thymus morphology ( J:34311 )

abnormal thymus cortex morphology ( J:34311 )

• the cortex contains more densely packed cells but is otherwise normal

abnormal thymus medulla morphology ( J:34311 )

• the medulla is smaller and contains few compacted cells

decreased thymocyte number ( J:34311 )

• in 4 week old homozygotes the number of thymocytes is reduced from 7- to 60-fold compared to wild-type littermates

abnormal T cell differentiation ( J:34311 )

increased double-negative T cell number ( J:34311 )

• double negative and CD25+ cells are proportionally overrepresented

arrested T cell differentiation ( J:34311 )

• differentiation of alphabeta precursors beyond the CD25+ double negative stage is impaired and Tcrb gene rearrangement is absent

increased gamma-delta T cell number ( J:34311 )

• CD3epsilon+ gammadelta+ cells are proportionally overrepresented

decreased T cell number ( J:34311 )

• CD3epsilon+ alphabeta+ T cells are proportionally underrepresented

decreased double-positive T cell number ( J:34311 )

• double positive T cells are proportionally underrepresented

decreased single-positive T cell number ( J:34311 )

• single positive cells are proportionally underrepresented

endocrine/exocrine glands

abnormal thymus morphology ( J:34311 )

abnormal thymus cortex morphology ( J:34311 )

• the cortex contains more densely packed cells but is otherwise normal

abnormal thymus medulla morphology ( J:34311 )

• the medulla is smaller and contains few compacted cells

decreased thymocyte number ( J:34311 )

• in 4 week old homozygotes the number of thymocytes is reduced from 7- to 60-fold compared to wild-type littermates