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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ndst1tm1Grob
targeted mutation 1, Kay Grobe
MGI:3588580
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ndst1tm1Grob/Ndst1tm1Grob
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:4943277
cn2
 		Ndst1tm1Grob/Ndst1tm1Grob
Ndst2tm1Lkj/Ndst2tm1Lkj
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J MGI:5430386
cn3
 		Ndst1tm1Grob/Ndst1tm1Grob
Tg(Pax6-cre,GFP)1Pgr/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4943274
cn4
 		Ndst1tm1Grob/Ndst1tm1Grob
Ndst2tm1Lkj/Ndst2tm1Lkj
Tg(Pax6-cre,GFP)1Pgr/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4943275


Genotype
MGI:4943277
cn1
Allelic
Composition		 Ndst1tm1Grob/Ndst1tm1Grob
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Ndst1tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:130571 )
N
• lacrimal gland development is normal




Genotype
MGI:5430386
cn2
Allelic
Composition		 Ndst1tm1Grob/Ndst1tm1Grob
Ndst2tm1Lkj/Ndst2tm1Lkj
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Ndst1tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
Ndst2tm1Lkj mutation (0 available); any Ndst2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal lacrimal gland development ( J:185652 )
• disruption of lacrimal gland budding

endocrine/exocrine glands
abnormal lacrimal gland development ( J:185652 )
• disruption of lacrimal gland budding




Genotype
MGI:4943274
cn3
Allelic
Composition		 Ndst1tm1Grob/Ndst1tm1Grob
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
Tg(Pax6-cre,GFP)1Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal lacrimal gland development ( J:130571 )
• reduced in 50% of newborn mice due to impaired budding and defective cell proliferation
absent lacrimal glands ( J:130571 )
• in 46% of mice

vision/eye
abnormal lacrimal gland development ( J:130571 )
• reduced in 50% of newborn mice due to impaired budding and defective cell proliferation
absent lacrimal glands ( J:130571 )
• in 46% of mice




Genotype
MGI:4943275
cn4
Allelic
Composition		 Ndst1tm1Grob/Ndst1tm1Grob
Ndst2tm1Lkj/Ndst2tm1Lkj
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndst1tm1Grob mutation (0 available); any Ndst1 mutation (47 available)
Ndst2tm1Lkj mutation (0 available); any Ndst2 mutation (28 available)
Tg(Pax6-cre,GFP)1Pgr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
absent lacrimal glands ( J:130571 )
• in all mice

vision/eye
absent lacrimal glands ( J:130571 )
• in all mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory