Analysis Tools
mortality/aging
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• the average age of reproductive senescence is younger in transgenic female mice than in controls
• however, general fertility and duration of the estrous cycle is unaffected in adult transgenic females
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nervous system
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• both female and male mice exhibit reduced numbers; however, the males exhibit a greater reduction
• the difference is visible at the level of the organum vasculosum of the lamina terminalis
• the tissue distribution pattern of the remaining cells is similar to controls
• gonadotropin-releasing hormone neuronal fiber density in the median eminence (the hormone release site) was slightly reduced
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• immunohistochemical analysis shows significantly reduced numbers of gonadotropin-releasing hormone neurons are present in the adult forebrai
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• reduced gonadotropin-releasing hormone concentration in the hypothalamus is shown in females
• significantly reduced gonadotropin-releasing hormone concentration in the hypothalamus is shown in males
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reproductive system
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• reduced gonadosomatic index (testis weight/body weight) is shown
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• the average age of reproductive senescence is younger in transgenic female mice than in controls
• however, general fertility and duration of the estrous cycle is unaffected in adult transgenic females
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• delayed puberty is indicated at 30 days of age by a failure of vaginal opening in transgenic females compared to controls
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• the size of the first litter is smaller than controls, but subseqent litters have similar numbers to controls
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endocrine/exocrine glands
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• reduced gonadosomatic index (testis weight/body weight) is shown
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homeostasis/metabolism
| N |
• serum lutenizing hormone levels are not different from controls
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