All Phenotypes Espl1<Gt(XL058)Byg> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Espl1^Gt(XL058)Byg/Espl1^Gt(XL058)Byg
Genetic Background	B6.129P2-Espl1^Gt(XL058)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^Gt(XL058)Byg mutation (1 available); any Espl1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation ( J:174926 )

• die at E6.5

Allelic Composition	Espl1^Gt(XL058)Byg/Espl1⁺
Genetic Background	B6.129P2-Espl1^Gt(XL058)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^Gt(XL058)Byg mutation (1 available); any Espl1 mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor incidence ( J:174926 )

• longer mean average tumor free lifespan (more than 800 days vs. 600 days for wild-type)

• no tumors are observed during the lifespan of mice compared to about 5% tumor incidence in wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:174926 )

• median survival of 118 day

neoplasm

abnormal tumor pathology ( J:174926 )

• increased levels of proliferation and DNA damage are seen in lung tissue affected by lymphoma

increased metastatic potential ( J:174926 )

• lymphomas are more aggressive and most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney

increased tumor cell proliferation ( J:174926 )

• increased levels of proliferation are seen in lung tissue affected by lymphoma

increased lymphoma incidence ( J:174926 )

• develop aggressive and widespread lymphomas involving the lung, liver, thymus, bone marrow and peripheral blood with a significantly reduced latency compared to mice null for Trp53 alone

• about 86% of mice develop lymphomas

• seldom localized to the thymus

• most commonly infiltrate the lungs, liver and spleen with less frequent infiltration of the colon and kidney

• lymphoma cells often completely deplete the lungs, liver and spleen completely obscuring the normal anatomy of these tissues

• significant invasion of the bone marrow is seen

increased carcinoma incidence ( J:174926 )

• develop carcinomas in various organs with a significantly reduced latency compared to mice null for Trp53 alone

hematopoietic system

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

abnormal splenocyte morphology ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

abnormal bone marrow cell physiology ( J:174926 )

• increased proliferation in pre-neoplastic bone marrow cells

cellular

aneuploidy ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

immune system

increased splenocyte proliferation ( J:174926 )

• in pre-neoplastic splenocytes

abnormal splenocyte morphology ( J:174926 )

• accumulation of aneuploidy in splenocytes is seen as early as 2.5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lymphoma		DOID:0060058		J:174926

Allelic Composition	Espl1^Gt(XL058)Byg/Espl1⁺ Trp53^tm1Tyj/Trp53⁺
Genetic Background	B6.129-Trp53^tm1Tyj Espl1^Gt(XL058)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^Gt(XL058)Byg mutation (1 available); any Espl1 mutation (92 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased carcinoma incidence ( J:174926 )

• about 50% of mice develop carcinomas over a period of 460 days which is an increased incidence compared to mice heterozygous for the Trp53 mutation alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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