Phenotypes associated with this allele

• Allele Symbol: Igh-J^tm1Mcdl
• Allele Name: targeted mutation 1, Maria A Curotto de Lafaille
• Allele ID: MGI:3586521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Igh-J^tm1Mcdl/Igh-J^tm1Mcdl Igk-J^tm1Mcdl/Igk-J^tm1Mcdl Rag1^tm1Mom/Rag1^tm1Mom Tg(DO11.10)10Dlo/?	involves: 129S/Sv * BALB/c * C3H * C57BL/6	MGI:3586594

Genotype
MGI:3586594

cx1

• Allelic Composition: Igh-J^tm1Mcdl/Igh-J^tm1Mcdl; Igk-J^tm1Mcdl/Igk-J^tm1Mcdl; Rag1^tm1Mom/Rag1^tm1Mom; Tg(DO11.10)10Dlo/?
• Genetic Background: involves: 129S/Sv * BALB/c * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:100072 )

• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice

abnormal spleen germinal center morphology ( J:100072 )

• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice

increased IgE level ( J:100072 )

• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal

increased IgG level ( J:100072 )

• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

hematopoietic system

abnormal T cell differentiation ( J:100072 )

• the development of IL-4+IFNG- and IFNG+IL-4- T cells after immunization are increased but not if wild-type splenocytes are transferred into mutant mice

abnormal spleen germinal center morphology ( J:100072 )

• germinal center formation is increased in mutants but not if wild-type splenocytes are transferred into mutant mice

increased IgE level ( J:100072 )

• following immunization with a cross-linked OVA-HA antigen IgE levels are elevated by 2 orders of magnitude compared to mutant mice wild-type for Rag1; however serum Ig half-lives are normal

increased IgG level ( J:100072 )

• following immunization with a cross-linked OVA-HA antigen IgG titers are increased compared to mutant mice wild-type for Rag1, with IgG1 titers increased about 20-fold

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyper IgE recurrent infection syndrome 1		DOID:3261	OMIM:147060	J:100072