Phenotypes associated with this allele

• Allele Symbol: Ttl^tm1Wehl
• Allele Name: targeted mutation 1, Juergen Wehland
• Allele ID: MGI:3584264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttl^tm1Wehl/Ttl^tm1Wehl	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c)	MGI:3603825

Genotype
MGI:3603825

hm1

• Allelic Composition: Ttl^tm1Wehl/Ttl^tm1Wehl
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * BALB/c)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:99877 )

respiratory system

abnormal breathing pattern ( J:99877 )

• defective breathing

nervous system

abnormal neuron differentiation ( J:99877 )

• in culture hippocampal and cortical neurons show premature and abnormal axonal differentiation and increased neuritic growth rate, neuritic length variations, and axonal growth rate

abnormal forebrain development ( J:99877 )

• at E15 only a few thalamic axons have crossed the diencephalic-telencephalic boundary and by E17 thalamic axons have deviated from their normal route and looped around

abnormal telencephalon development ( J:99877 )

• at E15 and E17 most cortico-thalamic axons that should exit to form the internal capsule fail to exit the neocortex

absent brain internal capsule ( J:99877 )

• the internal capsule is not formed

abnormal stratification in cerebral cortex ( J:99877 )

• at E19.5 organization of the cortical layers appears blurred

behavior/neurological

ataxia ( J:99877 )

cellular

abnormal neuron differentiation ( J:99877 )

• in culture hippocampal and cortical neurons show premature and abnormal axonal differentiation and increased neuritic growth rate, neuritic length variations, and axonal growth rate