Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkitm1Mtop mutation
(0 available);
any
Dgki mutation
(38 available)
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behavior/neurological
 N |
• mice exhibit normal acoustic startle response, performance in an elevated plus maze, behavior in an open field test, and sucrose preference
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• due to deficiency in postnatal care, offspring of mothers exhibit a slightly worse survival within the first two days after birth compared with offspring of wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkitm1Mtop mutation
(0 available);
any
Dgki mutation
(38 available)
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neoplasm
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N |
• application of PMA or by full-thickness skin wounding did not cause skin tumors in absence of the v-Ha-ras transgene
• homozygous mice had a normal gender ratio, were grossly normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkhem1Mjz mutation
(0 available);
any
Dgkh mutation
(55 available)
Dgkitm1Mtop mutation
(0 available);
any
Dgki mutation
(38 available)
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behavior/neurological
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N |
• mice exhibit normal acoustic startle response and behavior in an open field test
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• female mice exhibit enhanced sucrose preference compared with single homozygotes
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• female mice exhibit decreased immobility in the forced swim test
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• female mice spend more time in the closed arms of an elevated plus maze compared with wild-type mice
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• dams that fail to retrieve pups exhibit manic-like exploratory behavior
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• female mice exhibit disrupted sleep patterns with variations in total amount of time spent asleep (longer average wake bout throughout the light phase and shorter first half of the dark phase at ZT12-18) compared with wild-type mice
• however, the average length of individual sleep bouts is normal
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• due to deficiency in postnatal care, offspring of mothers exhibit decreased survival within the first two days after birth, reduced milk consumption, and slow postnatal weight gain compared with offspring of wild-type mice
• however, pups raised by wild-type dams exhibit normal survival
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkitm1Mtop mutation
(0 available);
any
Dgki mutation
(38 available)
Tg(Hba-x-v-Ha-ras)TG.ACLed mutation
(1 available)
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neoplasm
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• skin tumors induced by application of PMA or by full-thickness skin wounding are fewer in Dgkitm1Mtop homozygotes carrying the v-Ha-ras transgene compared to wild-type, transgene-positive mice
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Analysis Tools