Phenotypes associated with this allele

• Allele Symbol: Tg(TcraTcrbNY8.3)1Pesa
• Allele Name: transgene insertion 1, Pere Santamaria
• Allele ID: MGI:3584121
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraTcrbNY8.3)1Pesa/0	NOD.Cg-Rag2^tm1Fwa Tg(TcraTcrbNY8.3)1Pesa	MGI:3618784
tg2	Tg(TcraTcrbNY8.3)1Pesa/?	involves: C57BL/6 * NOD * SJL	MGI:3584136

Genotype
MGI:3618784

cx1

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(TcraTcrbNY8.3)1Pesa/0
• Genetic Background: NOD.Cg-Rag2^tm1Fwa Tg(TcraTcrbNY8.3)1Pesa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:94192 )

• females develop diabetes at lower frequencies and later ages than wild-type Rag2 NOD transgenics

Genotype
MGI:3584136

tg2

• Allelic Composition: Tg(TcraTcrbNY8.3)1Pesa/?
• Genetic Background: involves: C57BL/6 * NOD * SJL

immune system

pancreas inflammation ( J:44202 )

• insulitis at 3 weeks less than in controls

• insulitis at 6 weeks of age significantly greater than in controls

homeostasis/metabolism

increased circulating glucose level ( J:44202 )

• diabetes develops in 26% (males) to 33% (females) of mice

• diabetes slow to develop and moderate

endocrine/exocrine glands

pancreas inflammation ( J:44202 )

• insulitis at 3 weeks less than in controls

• insulitis at 6 weeks of age significantly greater than in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:44202