Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Krj mutation
(1 available);
any
Bdnf mutation
(41 available)
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nervous system
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N |
• dendritic arborization of layer 2/3 pyramidal neurons in the visual cortex is normal at 3 weeks and at 4 months
• basal response properties of the visual cortex are normal
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• GABAergic innervation of the visual cortex is deficient
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• distal segment density of both basal and apical dendrites is elevated at 4 months of age
• spine length and head diameter are not altered at 4 months as they are in controls
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• recovery from monocular deprivation in the visual cortex fails to occur as expected
• maintenance of cortical responsiveness is impaired
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• spontaneous firing rate deviates from controls
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behavior/neurological
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• at 1 month of age 78% of mutants clutch compared to 8% of wild-type mice and by 6 months all mutants clutch compared to 16% of wild-type
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• at 4 - 5 weeks of age performance on the rotarod test is impaired
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nervous system
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• tyrosine hydroxylase-positive neurons are reduced by about 27% and 23% at postnatal day 0 and 120, respectively and appear disorganized
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• the extent of the substantia nigra pars compacta appears reduced in coronal sections but the density of calbindin-positive neurons appears increased
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mortality/aging
nervous system
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• the cross-sectional area of medium spiny neuron soma is reduced by 25% and the diameter of all portions of the dendritic tree is reduced by about 40% compared to wild-type mice with spine density reduced by 30-40% at every order of dendrite
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• the striatal volume is reduced by 15% at P14 and by 33% and P35 and P120
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• hippocampal volume is reduced by 12% at 14 days of age however by 120 days of age no significant reduction in hippocampal volume is seen
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• cortical volume is reduced by 16% at P14, by about 25% at P35, and by 30% at P120
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• in layer II/III of the visual cortex soma area is normal at 2 weeks of age but reduced by 28% and 29% at 3 and 5 weeks of age, respectively; however the number of neurons is not significantly different compared to wild-type mice
• in layer II/III of the visual cortex basal dendrite branching is normal at 2 weeks of age, but reduced by 29% at 5 weeks of age with distal branches more severely affected than proximal branches
• in layer II/III of the visual cortex the number of primary dendrites is normal at 2 weeks of age but reduced by 19% and 36% at 3 and 5 weeks of age, respectively, compared to wild-type mice
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• at 5 weeks of age the thickness of the somatosensory and visual cortex are reduced by 12% and 17%, respectively and a 22% increase in neuron density is seen in layer II/III of the visual cortex compared to wild-type mice
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behavior/neurological
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• all mutants display limb clasping by 120 days of age and clasping progresses with age from only hindlimbs to include hind and forlimbs; however no impairment od motor function is seen in the rotarod test
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growth/size/body
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• body weight is reduced at 3 and 5 weeks of age
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• a 35% increase in body mass is seen at 16 weeks of age
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reproductive system
vision/eye
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• mutants open their eyes 1 day later
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growth/size/body
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N |
• forebrain specific heterozygotes do not become obese unlike mice heterozygous for Bdnftm1Lfr
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Analysis Tools