Phenotypes associated with this allele

• Allele Symbol: Tg(BCR/ABL)623Hkp
• Allele Name: transgene insertion 623, Nora Heisterkamp
• Allele ID: MGI:3582388
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Crkl^tm1Hkp/Crkl^tm1Hkp Tg(BCR/ABL)623Hkp/?	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA	MGI:3723274
cx2	Ikzf1^tm1Kast/Ikzf1^+ Tg(BCR/ABL)623Hkp/0	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:4819230
cx3	Rac3^tm1Hkp/Rac3^tm1Hkp Tg(BCR/ABL)623Hkp/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:3582413
tg4	Tg(BCR/ABL)623Hkp/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:3582414
tg5	Tg(BCR/ABL)623Hkp/0	involves: C57BL/6 * CBA	MGI:3582403
tg6	Tg(BCR/ABL)623Hkp/?	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA	MGI:3723282

Genotype
MGI:3723274

cx1

• Allelic Composition: Crkl^tm1Hkp/Crkl^tm1Hkp; Tg(BCR/ABL)623Hkp/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:76680 )

• average survival is 158 days

perinatal lethality, incomplete penetrance ( J:76680 )

• incomplete penetrance

neoplasm

increased leukemia incidence ( J:76680 )

• develop B-lineage leukemia to the same extent as mice expressing the transgene alone

increased B cell derived lymphoma incidence ( J:76680 )

• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone

Genotype
MGI:4819230

cx2

• Allelic Composition: Ikzf1^tm1Kast/Ikzf1⁺; Tg(BCR/ABL)623Hkp/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

neoplasm

increased acute lymphoblastic leukemia incidence ( J:160846 )

• mice develop B cell acute lymphoblastic leukemia with a median latency of 5.7 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:160846

Genotype
MGI:3582413

cx3

• Allelic Composition: Rac3^tm1Hkp/Rac3^tm1Hkp; Tg(BCR/ABL)623Hkp/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

mortality/aging

premature death ( J:99168 )

• mean life span for females is 321 +/- 59 days significantly longer than females wild-type for Rac3 (193 +/- 29 days); however, mean life span for males is not significantly different from males wild-type for Rac3

neoplasm

increased leukemia incidence ( J:99168 )

• mutants develop B-lineage lymphoblastic leukemia

Genotype
MGI:3582414

tg4

• Allelic Composition: Tg(BCR/ABL)623Hkp/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

mortality/aging

premature death ( J:99168 )

• mean life span for females is 193 +/- 29 days significantly shorter than females homozygous for Rac3^tm1Hkp (321 +/- 59 days); however, mean life span for males is not significantly different

neoplasm

increased leukemia incidence ( J:99168 )

• mutants develop B-lineage lymphoblastic leukemia

Genotype
MGI:3582403

tg5

• Allelic Composition: Tg(BCR/ABL)623Hkp/0
• Genetic Background: involves: C57BL/6 * CBA

neoplasm

increased leukemia incidence ( J:89786 )

• pre-B cell leukemia

increased acute lymphoblastic leukemia incidence ( J:160846 )

• mice develop B cell acute lymphoblastic leukemia with a median latency of 14.7 weeks

increased B cell derived lymphoma incidence ( J:89786 )

• pre-B cell lymphoma

Genotype
MGI:3723282

tg6

• Allelic Composition: Tg(BCR/ABL)623Hkp/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA

mortality/aging

premature death ( J:76680 )

• average survival is 200 days

neoplasm

increased leukemia incidence ( J:76680 )

• develop B-lineage leukemia

increased B cell derived lymphoma incidence ( J:76680 )

• develop B-lineage lymphoma