Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4tm1.2Dron mutation
(3 available);
any
Eif2ak4 mutation
(88 available)
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behavior/neurological
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• homozygotes display impaired contextual fear conditioning but normal auditory fear conditioning
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• homozygotes display impaired hippocampus-dependent spatial memory in a Morris water maze with repeated trials (strong conditioning) but improved spatial memory with a single trial (weak conditioning)
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nervous system
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• a single tetanus induces a robust and sustained late LTP unlike in wild-type mice where a single tetanus induces early LTP
• after repeated tetanic stimulation (4 trains at 100 Hz) the duration of late LTP is reduced, returning to baseline within 3 hours
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4tm1.2Dron mutation
(3 available);
any
Eif2ak4 mutation
(88 available)
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behavior/neurological
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• mice have much less of an aversion to diets lacking an essential amino acid
• mice consume 7.7% less leucine-deficient chow after 1 hour compared to wild-type mice that consume 28.8% less
• mice consume 9.4% less leucine-deficient chow after 4 hours compared to wild-type mice that consume 34.1% less
• similar responses are observed in threonine-deficient diet
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak4tm1.2Dron mutation
(3 available);
any
Eif2ak4 mutation
(88 available)
|
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immune system
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• splenic CD19+ dendritic cells treated with CTLA4-immunoglobulin do not produce IFNalpha, indicating a defect in response to CD80/86 (B7) ligation; production induced by TLR9 stimulation is equivalent to that in wild-type
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• splenic CD19+ dendritic cells do not secrete IFNalpha upon CTLA4-Ig treatement
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Analysis Tools