Thumpd1^em1Meij
Endonuclease-mediated Allele Detail

Summary

• Symbol: Thumpd1^em1Meij
• Name: THUMP domain containing 1; endonuclease-mediated mutation 1, Jordan L Meier
• MGI ID: MGI:8209553
• Gene: Thumpd1 Location: Chr7:119314316-119320021 bp, - strand Genetic Position: Chr7, 64.13 cM
• Alliance: Thumpd1^em1Meij page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exons 1 and 4 created an ~880 bp frameshift deletion. (J:363949)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thumpd1 Mutation: 13 strains or lines available

References

• Original: J:363949 Thalalla Gamage S, et al., Transfer RNA acetylation regulates in vivo mammalian stress signaling. Sci Adv. 2025 Mar 21;11(12):eads2923
• All: 1 reference(s)