Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd180tm1Kmiy mutation
(5 available);
any
Cd180 mutation
(52 available)
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immune system
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• impaired proliferative and humoral immune responses of B cells to lipopolysaccharides
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• reduced in serum at 7 and 11 weeks of age
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• significantly reduced in serum at 7 and 11 weeks of age
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hematopoietic system
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• reduced in serum at 7 and 11 weeks of age
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• significantly reduced in serum at 7 and 11 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd180tm1Kmiy mutation
(5 available);
any
Cd180 mutation
(52 available)
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immune system
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• significantly lower in serum at 20 weeks than in Cd180tm1Kmiy/+ heterozygous mice on this background
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• significantly lower in serum at 20 weeks than in Cd180tm1Kmiy/+ heterozygous mice on this background
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hematopoietic system
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• significantly lower in serum at 20 weeks than in Cd180tm1Kmiy/+ heterozygous mice on this background
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• significantly lower in serum at 20 weeks than in Cd180tm1Kmiy/+ heterozygous mice on this background
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mortality/aging
N |
• Cd180-deficiency ameliorates mortality in Faslpr mice; survival to >40 weeks is significantly greater than Faslpr homozygotes
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hematopoietic system
N |
• numbers of CD4-positive T cells are rescued relative to MRL/MpJ-Faslpr
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• severe in double mutants compared to controls, but reduced significantly from that observed in MRL/MpJ-Faslpr homozygotes
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• significantly increased relative to controls, similar to MRL/MpJ-Faslpr homozygotes
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• CD44+ and CD69+ B cells in spleen are decreased relative to wild-type controls
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• reduced compared to wild-type controls, but higher than in MRL/MpJ-Faslpr homozygotes
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• significantly lower in serum at 20 weeks than in MRL/MpJ-Faslpr single mutant mice
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• significantly reduced in serum at 20 weeks than in MRL/MpJ-Faslpr single mutant mice
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cardiovascular system
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• necrotizing arteritis of small- and medium-sized arteries in kidneys is observed less frequently than in MRL/MpJ-Faslpr mice
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renal/urinary system
immune system
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• necrotizing arteritis of small- and medium-sized arteries in kidneys is observed less frequently than in MRL/MpJ-Faslpr mice
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• severe in double mutants compared to controls, but reduced significantly from that observed in MRL/MpJ-Faslpr homozygotes
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• significantly increased relative to controls, similar to MRL/MpJ-Faslpr homozygotes
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• CD44+ and CD69+ B cells in spleen are decreased relative to wild-type controls
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• reduced compared to wild-type controls, but higher than in MRL/MpJ-Faslpr homozygotes
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• significantly lower in serum at 20 weeks than in MRL/MpJ-Faslpr single mutant mice
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• significantly reduced in serum at 20 weeks than in MRL/MpJ-Faslpr single mutant mice
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• severe compared to wild-type controls, but reduced significantly from that observed in MRL/MpJ-Faslpr homozygotes with largest difference in node size observed in axillary lymph nodes
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• autoantibody levels are much higher than wild-type controls but no difference is observed in IgG3 anti-IgG2a rheumatoid factor levels compared to MRL/MpJ-Faslpr homozygotes
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• levels of anti-dsDNA and anti-chromatin autoantibodies are elevated compared to wild-type, but are similar to MRL/MpJ-Faslpr homozygotes
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homeostasis/metabolism
growth/size/body
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• severe in double mutants compared to controls, but reduced significantly from that observed in MRL/MpJ-Faslpr homozygotes
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