All Phenotypes Steap3<+> MGI Mouse

abnormal erythrocyte morphology ( J:103440 )

increased erythrocyte cell number ( J:103440 )

• the hematocrit of 8 week old mice bearing the deletion in trans with the targeted allele is about 75% that of wild-type mice

decreased hemoglobin content ( J:103440 )

• blood of 8 week old complex heterozygous mice has a hemoglobin (g/dl) content about 65% that of blood from wild-type mice

decreased mean corpuscular hemoglobin ( J:103440 )

• red blood cells of 8 week old complex heterozygous mice contain only about 38% as much hemoglobin (pg) as RBCs of wild-type mice

decreased mean corpuscular hemoglobin concentration ( J:103440 )

• the hemoglobin concentration in red blood cells from 8 week old complex homozygotes is about 83% that of wild-type mice

decreased mean corpuscular volume ( J:103440 )

• 8 week old complex heterozygotes have a mean RBC volume approximately 45% that of wild-type mice

anisopoikilocytosis ( J:103440 )

• red blood cells of complex heterozygotes vary in shape and size

thrombocytosis ( J:103440 )

• the platelet count of 8 week old complex heterozygous mice is about 4.27 times that of wild-type mice

abnormal reticulocyte morphology ( J:103440 )

• reticulocytes of 8 week old complex heterozygous mice contain approximately half the cellular hemoglobin of those from wild-type mice

reticulocytosis ( J:103440 )

• in blood of 8 week old complex heterozygotes, both the absolute number and the proportion of reticulocytes are significantly elevated over those in blood of mice with at least one wild-type allele

abnormal iron homeostasis ( J:103440 )

• the erythrocyte zinc-to-iron protoporphyrin IX ratio of 8 week old complex heterozygous mice is approximately 4.7-fold that of wild-type mice

increased liver iron level ( J:103440 )

• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice

increased liver iron level ( J:103440 )

• the liver iron content of complex heterozygotes is approximately 3-fold that of wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24