Phenotypes associated with this allele

• Allele Symbol: Emx2^tm2(cre)Sia
• Allele Name: targeted mutation 2, Shinichi Aizawa
• Allele ID: MGI:3579416
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk Emx2^tm2(cre)Sia/Emx2^+	involves: C57BL/6NCrlj * CBA/JNCrlj	MGI:5440721

Genotype
MGI:5440721

cn1

• Allelic Composition: Setdb1^tm1.1Yshk/Setdb1^tm1.1Yshk; Emx2^tm2(cre)Sia/Emx2⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:188109 )

• born alive but do not survive beyond P10

nervous system

increased neuron apoptosis ( J:188109 )

• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex

abnormal neuronal precursor proliferation ( J:188109 )

• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation

abnormal cerebral cortex morphology ( J:188109 )

• decrease in the number of early born layer V and VI neurons at E12.5

• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5

• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5

• smaller cortex at E18.5 and P7

• severe reduction in the number of Ctip2+ layer V and VI neurons at P7

loss of cortex neurons ( J:188109 )

• increase in apoptosis at E13.5, primarily located in layers V-VI

abnormal astrocyte morphology ( J:188109 )

• increase in the number of astrocytes in the cortex at E18.5 and P7

abnormal nervous system development ( J:188109 )

• in culture neural progenitor cells from E14.5 embryos more readily differentiate into astrocytes

abnormal neuron differentiation ( J:188109 )

• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex

abnormal telencephalon development ( J:188109 )

• impairment of early neurogenesis indicated by decrease in the populations of deep layer neurons at E18.5

• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex

• partial reduction in the migration of GABAergic neurons into the dorsal telencephalon at E18.5

abnormal cortical plate morphology ( J:188109 )

• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5

decreased neuronal precursor cell number ( J:188109 )

• decrease in the number of basal progenitors (Tbr2+) at E11.5 and E12.5

decreased neuron number ( J:188109 )

• decrease in the number of early born layer V and VI neurons at E12.5

• decrease in the number of Ctip2+ layer V and VI neurons, Tbr1+ layer VI neurons and Tbr2+ basal progenitors in the cortex at E14.5 and E16.5

increased neuron number ( J:188109 )

• increase in the number of Cux1+ and Satb2+ upper layer neurons at E18.5

• increase in the number of Brn2+ layer II-III neurons in the cortical plate at E14.5 and E16.5

cellular

increased neuron apoptosis ( J:188109 )

• increase in apoptosis at E13.5, primarily located in layers V-VI of the cortex

abnormal neuron differentiation ( J:188109 )

• premature acceleration of the production of late born upper layer neurons and deceleration of the production of early born deep layer neurons in the cerebral cortex

abnormal neuronal precursor proliferation ( J:188109 )

• in culture ventricular zone cells are less likely to develop into neurospheres of greater than 50 um in diameter indicating impaired proliferation