Phenotypes associated with this allele

• Allele Symbol: H2^s
• Allele Name: s variant
• Allele ID: MGI:3579325
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^b/H2^s Tg(TcraTcrb)1100Mjb/?	involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss	MGI:3783840

Genotype
MGI:3783840

cx1

• Allelic Composition: H2^b/H2^s; Tg(TcraTcrb)1100Mjb/?
• Genetic Background: involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system

small thymus ( J:133645 )

• the thymus is smaller than normal

abnormal negative T cell selection ( J:133645 )

• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR

decreased CD8-positive, alpha-beta T cell number ( J:133645 )

• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands

small thymus ( J:133645 )

• the thymus is smaller than normal