Phenotypes associated with this allele

• Allele Symbol: Barx1^tm1Shiv
• Allele Name: targeted mutation 1, Ramesh A Shivdasani
• Allele ID: MGI:3578634
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Barx1^tm1Shiv/Barx1^tm1Shiv	either: B6.Cg-Barx1^tm1Shiv or 129S.Cg-Barx1^tm1Shiv or (involves: CD-1)	MGI:5307913
hm2	Barx1^tm1Shiv/Barx1^tm1Shiv	involves: 129	MGI:3579829
cx3	Barx1^tm1Shiv/Barx1^tm1Shiv Msx1^tm1Bero/Msx1^+	involves: 129P2/OlaHsd * various	MGI:5307914

Genotype
MGI:5307913

hm1

• Allelic Composition: Barx1^tm1Shiv/Barx1^tm1Shiv
• Genetic Background: either: B6.Cg-Barx1^tm1Shiv or 129S.Cg-Barx1^tm1Shiv or (involves: CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:180393 )

• Background Sensitivity: unlike mice on a mixed background with 129 that die at E13, mice on a variety of congenic backgrounds or a mixed background with CD-1 die shortly after birth due to cleft palate

craniofacial

abnormal tooth development ( J:180393 )

• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice

arrest of tooth development ( J:180393 )

• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice

• however, molar development is normal by E16.5

cleft palate ( J:180393 )

digestive/alimentary system

cleft palate ( J:180393 )

cellular

decreased cell proliferation ( J:180393 )

• in the epithelium and mesenchyme cells of molars between E13.5 and E14.5

increased cell proliferation ( J:180393 )

• in the epithelium and mesenchyme cells of molars between E15.5

growth/size/body

abnormal tooth development ( J:180393 )

• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice

arrest of tooth development ( J:180393 )

• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice

• however, molar development is normal by E16.5

cleft palate ( J:180393 )

skeleton

abnormal tooth development ( J:180393 )

• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice

arrest of tooth development ( J:180393 )

• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice

• however, molar development is normal by E16.5

Genotype
MGI:3579829

hm2

• Allelic Composition: Barx1^tm1Shiv/Barx1^tm1Shiv
• Genetic Background: involves: 129

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98305 )

• embyos die around E13

digestive/alimentary system

abnormal stomach morphology ( J:98305 )

• prior to death E12.5 embryo shows shrunken and malformed stomach but normal intestine

Genotype
MGI:5307914

cx3

• Allelic Composition: Barx1^tm1Shiv/Barx1^tm1Shiv; Msx1^tm1Bero/Msx1⁺
• Genetic Background: involves: 129P2/OlaHsd * various

craniofacial

arrest of tooth development ( J:180393 )

• permanent in molars at the bud stage

growth/size/body

arrest of tooth development ( J:180393 )

• permanent in molars at the bud stage

skeleton

arrest of tooth development ( J:180393 )

• permanent in molars at the bud stage