Phenotypes associated with this allele

• Allele Symbol: Arl13b^hnn
• Allele Name: hennin
• Allele ID: MGI:3578151
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arl13b^hnn/Arl13b^hnn	involves: C3HeB/FeJ * C57BL/6J	MGI:3580673
hm2	Arl13b^hnn/Arl13b^hnn	involves: C57BL/6J	MGI:5052338
cn3	Arl13b^hnn/Arl13b^tm1Tc Pax3^tm1(cre)Joe/Pax3^+	involves: 129S6/SvEvTac * C57BL/6J	MGI:5052337

Genotype
MGI:3580673

hm1

• Allelic Composition: Arl13b^hnn/Arl13b^hnn
• Genetic Background: involves: C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E13-E14

embryo

abnormal left-right axis patterning ( J:98216 )

• left-right randomization

absent floor plate ( J:98216 )

• no floor plate in the caudal spinal cord

nervous system

absent floor plate ( J:98216 )

• no floor plate in the caudal spinal cord

Genotype
MGI:5052338

hm2

• Allelic Composition: Arl13b^hnn/Arl13b^hnn
• Genetic Background: involves: C57BL/6J

embryo

spina bifida ( J:173637 )

• moderate spina bifida in the caudal neural tube

nervous system

spina bifida ( J:173637 )

• moderate spina bifida in the caudal neural tube

Genotype
MGI:5052337

cn3

• Allelic Composition: Arl13b^hnn/Arl13b^tm1Tc; Pax3^tm1(cre)Joe/Pax3⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:173637 )

• one surviving mouse died by P21

perinatal lethality, incomplete penetrance ( J:173637 )

• all but one mouse dies at birth after an episode of gasping unlike wild-type mice

respiratory system

respiratory distress ( J:173637 )

• all but one mouse dies at birth after an episode of gasping unlike wild-type mice

growth/size/body

decreased body size ( J:173637 )

• one surviving mouse