All Phenotypes Dync2h1<lln> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dync2h1^lln
ling-ling
MGI:3578144

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dync2h1^lln/Dync2h1^lln	involves: C3HeB/FeJ * C57BL/6J	MGI:3580678
hm2	Dync2h1^lln/Dync2h1^lln	involves: C57BL/6J	MGI:3624271
ht3	Dync2h1^{Gt(RRM278)Byg}/Dync2h1^lln	involves: 129P2/OlaHsd * C57BL/6J	MGI:3624273
cx4	Dync2h1^lln/Dync2h1^lln Ptch1^tm1Mps/Ptch1^tm1Mps	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3624275

Allelic Composition	Dync2h1^lln/Dync2h1^lln
Genetic Background	involves: C3HeB/FeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^lln mutation (0 available); any Dync2h1 mutation (215 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:98216 )

• die at E9.0

embryo

abnormal left-right axis patterning ( J:98216 )

• left-right randomization

nervous system

abnormal spinal cord morphology ( J:98216 )

• dorsalized spinal cord

Allelic Composition	Dync2h1^lln/Dync2h1^lln
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^lln mutation (0 available); any Dync2h1 mutation (215 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• homozygous mutants die around E12.5

embryo

embryo phenotype ( J:100466 )

N	• around E7.5, cilia present on the surface of the node are abnormal; some cilia are short while others are normal in length but have a bulge along their surface

cardiovascular system

abnormal direction of heart looping ( J:100466 )

• mutants exhibit randomization of heart looping polarity

limbs/digits/tail

polydactyly ( J:100466 )

• mutants surviving to E13.5 display polydactyly of the fore- and hind-limbs

nervous system

exencephaly ( J:100466 )

• about 50% of homozygotes are exencephalic and lack the groove at the ventral midline of the brain

Allelic Composition	Dync2h1^{Gt(RRM278)Byg}/Dync2h1^lln
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^{Gt(RRM278)Byg} mutation (0 available); any Dync2h1 mutation (215 available)
Dync2h1^lln mutation (0 available); any Dync2h1 mutation (215 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• mutants die around E12.5

cardiovascular system

abnormal direction of heart looping ( J:100466 )

• mutants exhibit randomization of heart looping polarity

nervous system

abnormal brain morphology ( J:100466 )

Allelic Composition	Dync2h1^lln/Dync2h1^lln Ptch1^tm1Mps/Ptch1^tm1Mps
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^lln mutation (0 available); any Dync2h1 mutation (215 available)
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:100466 )

• double mutants die around E12.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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