All Phenotypes Ep300<tm1Pkb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ep300^tm1Pkb
targeted mutation 1, Paul K Brindle
MGI:3578128

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ep300^tm1Pkb/Ep300^tm1Pkb	involves: 129P2/OlaHsd * C57BL/6	MGI:3578231
ht2	Ep300^tm1Pkb/Ep300⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3578232
cx3	Ep300^tm1Pkb/Ep300⁺ Myb^tm1Ssp/Myb⁺	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3578233

Allelic Composition	Ep300^tm1Pkb/Ep300^tm1Pkb
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300^tm1Pkb mutation (2 available); any Ep300 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:98329 )

• more than 80% lethality before weaning due to unknown causes, survivors are viable

hematopoietic system

decreased thymocyte number ( J:98329 )

• thymocytes reduced to about 5% of controls but peripheral single positive cell populations remained in normal range

anemia ( J:98329 )

• severe anemia

increased megakaryocyte cell number ( J:98329 )

• megakaryocyte hyperplasia in bone marrow with corresponding reductions in other bone marrow elements

abnormal erythrocyte morphology ( J:98329 )

anisocytosis ( J:98329 )

• erythrocytes of variable size

thrombocytosis ( J:98329 )

• thrombocytosis and increased numbers of megakaryocytes in circulation

growth/size/body

decreased body size ( J:98329 )

• body size was 50-70% of controls at 4 weeks of age

immune system

decreased thymocyte number ( J:98329 )

• thymocytes reduced to about 5% of controls but peripheral single positive cell populations remained in normal range

endocrine/exocrine glands

decreased thymocyte number ( J:98329 )

• thymocytes reduced to about 5% of controls but peripheral single positive cell populations remained in normal range

Allelic Composition	Ep300^tm1Pkb/Ep300⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300^tm1Pkb mutation (2 available); any Ep300 mutation (98 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytosis ( J:98329 )

• slight increase in platelets but otherwise normal

Allelic Composition	Ep300^tm1Pkb/Ep300⁺ Myb^tm1Ssp/Myb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ep300^tm1Pkb mutation (2 available); any Ep300 mutation (98 available)
Myb^tm1Ssp mutation (1 available); any Myb mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:98329 )

• 40% reduction in numbers

abnormal megakaryocyte morphology ( J:98329 )

• megakaryocyte ploidy reduced relative to controls

thrombocytosis ( J:98329 )

• large increase in platelet numbers seen at 2-3 weeks of age but not at 5-6 weeks

immune system

decreased thymocyte number ( J:98329 )

• 40% reduction in numbers

endocrine/exocrine glands

decreased thymocyte number ( J:98329 )

• 40% reduction in numbers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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