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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc11a2tm1Nca
targeted mutation 1, Nancy C Andrews
MGI:3577914
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc11a2tm1Nca/Slc11a2tm1Nca 129S6.129S4-Slc11a2tm1Nca MGI:3578656
ht2
 		Slc11a2tm1Nca/Slc11a2+ involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578657
cx3
 		Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca 		involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca MGI:3578659


Genotype
MGI:3578656
hm1
Allelic
Composition		 Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:98088 )
• by 7 days of age
• RBC transfusions prolong survival

hematopoietic system
decreased hemoglobin content ( J:98088 )
• by 3 days of age
anisocytosis ( J:98088 )
• diminished non-heme iron levels in liver, spleen, kidney, brain and heart
• liver iron levels elevated at birth

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:98088 )
N
• total body iron levels relatively normal

growth/size/body
postnatal growth retardation ( J:98088 )
• progressive postnatal growth retardation
• weigh 30% less than controls by 3 days of age

integument
pallor ( J:98088 )
• at birth




Genotype
MGI:3578657
ht2
Allelic
Composition		 Slc11a2tm1Nca/Slc11a2+
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased liver iron level ( J:98088 )
• by 8 weeks of age

liver/biliary system
decreased liver iron level ( J:98088 )
• by 8 weeks of age




Genotype
MGI:3578659
cx3
Allelic
Composition		 Hfetm2Nca/Hfetm2Nca
Slc11a2tm1Nca/Slc11a2tm1Nca
Genetic
Background		 involves: 129S6/SvEvTac * 129S6.129S4-Slc11a2tm1Nca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hfetm2Nca mutation (1 available); any Hfe mutation (34 available)
Slc11a2tm1Nca mutation (0 available); any Slc11a2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:98088 )
N
• considerably improved survival

homeostasis/metabolism
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age

hematopoietic system
decreased hematocrit ( J:98088 )
• but improved over condition seen in inSlc11a2 knockout mice

growth/size/body
postnatal growth retardation ( J:98088 )
• body weight considerably better than inSlc11a2 knockout mice at 12 weeks of age

liver/biliary system
increased liver iron level ( J:98088 )
• liver non-heme iron levels higher than in Slc11a2 knock-out mice at 12 weeks of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory