All Phenotypes Lrp6<skax26> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Lrp6^skax26
skeletal/axial 26
MGI:3577510

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp6^skax26/Lrp6^skax26	involves: 129S6/SvEvTac * C57BL/6J	MGI:5571492
hm2	Lrp6^skax26/Lrp6^skax26	involves: C57BL/6J	MGI:5007813
ht3	Lrp6^skax26/Lrp6⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:5571493
cx4	Lrp6^skax26/Lrp6⁺ Vangl2^Lp/Vangl2⁺	involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5571494

Allelic Composition	Lrp6^skax26/Lrp6^skax26
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^skax26 mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )

• only in the OHC3 layer of the apical region

limbs/digits/tail

curly tail ( J:206979 )

• kinky/looped tail in most mice

kinked tail ( J:206979 )

• kinky/looped tail in most mice

nervous system

abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )

• only in the OHC3 layer of the apical region

Allelic Composition	Lrp6^skax26/Lrp6^skax26
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^skax26 mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:89098 )

• described as a loop tail, variable penetrance

kinked tail ( J:89098 )

• described as a kinky tail after an outcross

Allelic Composition	Lrp6^skax26/Lrp6⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^skax26 mutation (0 available); any Lrp6 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:206979 )

• kinky/looped tail in a few mice

kinked tail ( J:206979 )

• kinky/looped tail in a few mice

Allelic Composition	Lrp6^skax26/Lrp6⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6^skax26 mutation (0 available); any Lrp6 mutation (95 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )

• everely affected in OHC2 and OHC3 layers at all three regions analyzed except for OHC3 in the middle region of the organ of Corti

limbs/digits/tail

curly tail ( J:206979 )

• kinky/looped tail in most mice

kinked tail ( J:206979 )

• kinky/looped tail in most mice

embryo

spina bifida ( J:206979 )

• in some mice unlike single heterozygotes

nervous system

spina bifida ( J:206979 )

• in some mice unlike single heterozygotes

abnormal orientation of outer hair cell stereociliary bundles ( J:206979 )

• everely affected in OHC2 and OHC3 layers at all three regions analyzed except for OHC3 in the middle region of the organ of Corti

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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