Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Senp1tm1Wami mutation
(0 available);
any
Senp1 mutation
(65 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation
(33 available);
any
Apoe mutation
(145 available)
Klf15tm2Jain mutation
(0 available);
any
Klf15 mutation
(17 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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Klf15tm2Jain/Klf15tm2Jain Tg(Tagln-cre)1Jjl/0 Apoetm1Unc/Apoetm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge
homeostasis/metabolism
immune system
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• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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cardiovascular system
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• in mice fed a high fat diet compared with Apoetm1Unc homozygotes
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• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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muscle
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• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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hematopoietic system
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• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoetm1Unc homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm2Msp mutation
(0 available);
any
Gata6 mutation
(32 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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mortality/aging
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• all die between E18.5 and P2
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cardiovascular system
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• 6 of 11 embryos show a retroesophageal right subclavian artery
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• 7 of 11 embryos exhibit a hypoplastic aortic arch
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• 7 of 11 embryos have an interrupted aortic arch
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• seen in 1/11 mutant mice
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• seen in 7 of 11 embryos
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• seen in 4 of 11 embryos
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• all embryos exhibit a membranous ventricular septal defect
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation
(10 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Smotm2Amc mutation
(1 available);
any
Smo mutation
(39 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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cardiovascular system
N |
• cardiopulmonary development is not disrupted
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pkn2tm1c(KOMP)Wtsi mutation
(0 available);
any
Pkn2 mutation
(84 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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mortality/aging
cardiovascular system
respiratory system
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• alveolar enlargement in survivors
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(MAML1)Wsp mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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growth/size/body
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• keratin cyst formation is observed
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• generalized growth retardation is observed compared to controls
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neoplasm
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• mice develop spontaneous cutaneous SCC lesions, as well as dysplastic precursor lesions
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limbs/digits/tail
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• with aging, hyperkeratinization of tail is seen
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integument
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• aberrant hair follicle cycling occurs
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• starting at 2-3 weeks, mice display hair and whisker loss; diffuse alopecia is observed
• at 10 months of age, alopecia has progressed almost to completion
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• hypoplastic dermis with increased cellularity is observed
• by 6 months of age, most mice develop hyperkeratotic cutaneous nodules, with all mutants exhibiting multiple lesions by 10 months of age
• examination of some nodules reveals papillomas or inflamed infundibular cyts
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• keratin cyst formation is observed
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• cutaneous nodules show hyperproliferative keratinocytic lesions exhibiting cellular atypia and an invasive growth pattern
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf15tm2Jain mutation
(0 available);
any
Klf15 mutation
(17 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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mortality/aging
N |
• mice are viable and born in expected Mendelian ratios
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1.1Kwhi mutation
(0 available);
any
Ccm2 mutation
(47 available)
Ccm2tm1Kwhi mutation
(0 available);
any
Ccm2 mutation
(47 available)
Tg(Tagln-cre)1Jjl mutation
(0 available)
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normal phenotype
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• no vasculature defects are observed during development
• homozygote mice are born at the expected ratios
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