Analysis Tools
growth/size/body
ovary cyst
(
J:97817
)
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• hemorrhagic ovarian cysts are occasionally seen at 8 weeks of age
• cysts are also seen at 20 weeks of age in some homozygous females
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reproductive system
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• significant oocyte death is seen at 20 weeks of age in some mutants along with oocytes lacking cumulus cells and interstitium full of zona pellucida remnants
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• in mutants with oocyte death at 20 weeks of age zona pellucida remnants are in the interstitium and the zona pellucidae are invaded by granulosa cells
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azoospermia
(
J:97817
)
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• increased numbers of apoptotic cells, mostly in meiotic prophase, are seen in the testes of 7 week old homozygous males
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• at 8 months of age, all nine homozygotes had ovaries containing abundant interstitial tissue
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• at 8 months of age, 5 out of 9 homozygous females had corpora lutae containing centrally trapped oocytes
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• by 21 day of age fewer follicles are seen and in many of those present the granulosa cells are disorganized, fewer follicles are also seen at 8 weeks of age
• at 20 weeks of age some ovaries had mostly preantral follicles with occasional follicles containing 2 oocytes and larger than normal oocytes
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small ovary
(
J:97817
)
|
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• at 8 months of age, 3 of 9 homozygous females had small ovaries lacking oocytis and follicles
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ovary cyst
(
J:97817
)
|
|
• hemorrhagic ovarian cysts are occasionally seen at 8 weeks of age
• cysts are also seen at 20 weeks of age in some homozygous females
|
small testis
(
J:97817
)
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• a block in late spermatogenesis as spermatids elongate is seen
• large, vacuolated spermatids and multinucleated condensed spermatids are frequently seen
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• juvenile homozygous females fail to ovulate in response to gonadotropin treatment
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endocrine/exocrine glands
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• at 8 months of age, all nine homozygotes had ovaries containing abundant interstitial tissue
|
|
|
• at 8 months of age, 5 out of 9 homozygous females had corpora lutae containing centrally trapped oocytes
|
|
|
• by 21 day of age fewer follicles are seen and in many of those present the granulosa cells are disorganized, fewer follicles are also seen at 8 weeks of age
• at 20 weeks of age some ovaries had mostly preantral follicles with occasional follicles containing 2 oocytes and larger than normal oocytes
|
small ovary
(
J:97817
)
|
|
• at 8 months of age, 3 of 9 homozygous females had small ovaries lacking oocytis and follicles
|
ovary cyst
(
J:97817
)
|
|
• hemorrhagic ovarian cysts are occasionally seen at 8 weeks of age
• cysts are also seen at 20 weeks of age in some homozygous females
|
small testis
(
J:97817
)
|
|
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cellular
|
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• significant oocyte death is seen at 20 weeks of age in some mutants along with oocytes lacking cumulus cells and interstitium full of zona pellucida remnants
|
|
|
• in mutants with oocyte death at 20 weeks of age zona pellucida remnants are in the interstitium and the zona pellucidae are invaded by granulosa cells
|
azoospermia
(
J:97817
)
|
|
|
|
|
• increased numbers of apoptotic cells, mostly in meiotic prophase, are seen in the testes of 7 week old homozygous males
|
