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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts5tm1.1Eam
targeted mutation 1.1, Elisabeth A Morris
MGI:3576786
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adamts5tm1.1Eam/Adamts5tm1.1Eam involves: 129S5/SvEvBrd MGI:3577950
ht2
 		Adamts5tm1.1Eam/Adamts5+ involves: 129S5/SvEvBrd MGI:3577954


Genotype
MGI:3577950
hm1
Allelic
Composition		 Adamts5tm1.1Eam/Adamts5tm1.1Eam
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Eam mutation (0 available); any Adamts5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction

skeleton
decreased susceptibility to induced arthritis ( J:97590 )
• after surgically induced joint instability (to induce osteoarthritis), saw a significant reduction in the severity of cartilage destruction




Genotype
MGI:3577954
ht2
Allelic
Composition		 Adamts5tm1.1Eam/Adamts5+
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Eam mutation (0 available); any Adamts5 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:97590 )
• severity of osteoarthritis was significantly reduced 8 weeks after induction of joint instability

skeleton
decreased susceptibility to induced arthritis ( J:97590 )
• severity of osteoarthritis was significantly reduced 8 weeks after induction of joint instability




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory