Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Selenontm1.1Mred mutation
(0 available);
any
Selenon mutation
(26 available)
Tg(ACTA1-cre/ERT2)97.16Mtz mutation
(0 available)
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normal phenotype
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• mice exhibit normal post-natal development, growth, and activity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grpel1tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Grpel1 mutation
(23 available)
Tg(ACTA1-cre/ERT2)97.16Mtz mutation
(0 available)
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muscle
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• disorganized in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• systemic metabolic alterations with decreased glycolysis and increased fatty acids in muscles of tamoxifen-treated mice
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homeostasis/metabolism
growth/size/body
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• in tamoxifen-treated mice without a change in movement, oxygen consumption, respiratory exchange ratio, or heat production
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behavior/neurological
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• in tamoxifen-treated mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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behavior/neurological
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• on a graded treadmill protocol, mutants treated with tamoxifen show a decrease in the time of drop off from the treadmill compared to controls
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• by 4 weeks after tamoxifen administration, 70% of mutants show reduced mobility
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• by 4 weeks after tamoxifen administration, 70% of mutants show abnormal gait
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muscle
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• mutants treated with tamoxifen exhibit increased numbers of smaller myocytes, scattered basophilic fibers, acute myofibrillar degeneration with significant numbers of necrotic fibers and many fibers with basophilic cytoplasm and central nuclei consistent with regeneration
• four weeks after tamoxifen administration, mutants show a loss in fibers expressing solely slow twitch myosin and an increase in the number of fibers showing simultaneous expression of slow and fast twitch myosin isoforms
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• by 4 weeks after tamoxifen administration, mutants show a severe reduction in muscle size
• muscle wasting progressively worsens with a 15% reduction in diameter by 4 weeks after tamoxifen administration
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• mutants treated with tamoxifen exhibit severe and progressive skeletal muscle wasting and degeneration
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• mutants treated with tamoxifen exhibit focal regions with increased fibrosis in skeletal muscle
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• mutants treated with tamoxifen to induce cre-recombination exhibit sustained myotonia, with waxing and waning myotonic runs noted on electromyogram
• mutants not treated with tamoxifen also develop myotonia, indicating basal leakiness of the transgene, however they do not show overt skeletal muscle wasting, histological abnormalities or muscle dysfunction as do tamoxifen treated mutants
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skeleton
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• by 4 weeks after tamoxifen administration, 70% of mutants show kyphosis
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Analysis Tools
