Selenon^tm1.1Mred
Targeted Allele Detail

Summary

• Symbol: Selenon^tm1.1Mred
• Name: selenoprotein N; targeted mutation 1.1, Mathieu Rederstorff
• MGI ID: MGI:5297977
• Synonyms: Sepn1 L2
• Gene: Selenon Location: Chr4:134265203-134279477 bp, - strand Genetic Position: Chr4, 66.85 cM, cytoband D3
• Alliance: Selenon^tm1.1Mred page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176499
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and left exon 3 floxed. (J:176499)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenon Mutation: 26 strains or lines available

References

• Original: J:176499 Rederstorff M, et al., Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS One. 2011;6(8):e23094
• All: 2 reference(s)