All Phenotypes Arhgap29<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Arhgap29^em1Cya/Arhgap29⁺	C57BL/6J-Arhgap29^em1Cya/Cya	MGI:8220140
ht2	Arhgap29^em1(IMPC)J/Arhgap29⁺	C57BL/6NJ-Arhgap29^em1(IMPC)J/J	MGI:6150842
ht3	Arhgap29^em1(IMPC)J/Arhgap29⁺	C57BL/6NJ-Arhgap29^em1(IMPC)J/J	MGI:6261893
ht4	Arhgap29^tm1Murr/Arhgap29⁺	C57BL/6NJ-Arhgap29^tm1Murr/GrsrJ	MGI:6150829
cx5	Arhgap29^tm1Murr/Arhgap29⁺ Mafb^tm1.2Mardu/Mafb⁺	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA	MGI:7256936

Allelic Composition	Arhgap29^em1Cya/Arhgap29⁺
Genetic Background	C57BL/6J-Arhgap29^em1Cya/Cya

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap29^em1Cya mutation (1 available); any Arhgap29 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart shape ( J:367731 )

craniofacial

abnormal palate development ( J:367731 )

• E14.5 embryos exhibit a delay in development of the palate such that palatal shelves do not reach the midline of the palate from the anterior palate, medial, to the posterior palate

digestive/alimentary system

abnormal palate development ( J:367731 )

• E14.5 embryos exhibit a delay in development of the palate such that palatal shelves do not reach the midline of the palate from the anterior palate, medial, to the posterior palate

growth/size/body

abnormal palate development ( J:367731 )

• E14.5 embryos exhibit a delay in development of the palate such that palatal shelves do not reach the midline of the palate from the anterior palate, medial, to the posterior palate

Allelic Composition	Arhgap29^em1(IMPC)J/Arhgap29⁺
Genetic Background	C57BL/6NJ-Arhgap29^em1(IMPC)J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap29^em1(IMPC)J mutation (1 available); any Arhgap29 mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial adhesions are found at E14.5, but fewer than are found in mice heterozygous for the em1Murr allele

digestive/alimentary system

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial adhesions are found at E14.5, but fewer than are found in mice heterozygous for the em1Murr allele

growth/size/body

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial adhesions are found at E14.5, but fewer than are found in mice heterozygous for the em1Murr allele

Allelic Composition	Arhgap29^em1(IMPC)J/Arhgap29⁺
Genetic Background	C57BL/6NJ-Arhgap29^em1(IMPC)J/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap29^em1(IMPC)J mutation (1 available); any Arhgap29 mutation (47 available)

Data Sources

IMPC Data for Arhgap29

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

IMPC - JAX

increased circulating aspartate transaminase level ( J:211773 )

IMPC - JAX

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

• intraoral epithelial contacts, including palatal shelf to tongue adhesions and tooth bud adhesions, are found in 75% of heterozygotes at E13.5 and 52% of heterozygotes at E14.5, but none in wild-type sibling controls, and by E18.5 the palates of heterozygotes are well-formed indicating and allow complete palatogenesis

embryo

abnormal periderm morphology ( J:257248 )

• the sites of some oral epithelial adhesions have flat periderm nuclei and the periderm layer is reported to be occossionally discontinuous or disorganized

digestive/alimentary system

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

growth/size/body

failure of palatal shelf elevation ( J:257248 )

• at E14.5 palatal shelves are elevated in only 72% of heterozygotes compared with 100% of wild-type controls

palatal shelf fusion with tongue or mandible ( J:257248 )

abnormal oral epithelium morphology ( J:257248 )

Allelic Composition	Arhgap29^tm1Murr/Arhgap29⁺ Mafb^tm1.2Mardu/Mafb⁺
Genetic Background	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap29^tm1Murr mutation (0 available); any Arhgap29 mutation (47 available)
Mafb^tm1.2Mardu mutation (0 available); any Mafb mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:311539 )

N	• mice born at normal Mendelian ratios

skeleton

skeleton phenotype ( J:311539 )

N	• normal palatogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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