Arhgap29^tm1Murr
Targeted Allele Detail

Summary

• Symbol: Arhgap29^tm1Murr
• Name: Rho GTPase activating protein 29; targeted mutation 1, Stephen Murray
• MGI ID: MGI:6150826
• Synonyms: K326X
• Gene: Arhgap29 Location: Chr3:121746752-121810326 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: Arhgap29^tm1Murr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257248
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Null/knockout)
• Mutations: Other, Single point mutation
• Mutation details: An A to T point substitution at base 1184 in exon 11 introduces a lysine to stop codon mutation at amino acid 325 (K325X), which is amino acid 326 in human. An FRT-flanked neomycin selection cassette was also introduced 3-prime of exon 11. (J:257248)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgap29 Mutation: 46 strains or lines available

References

• Original: J:257248 Paul BJ, et al., ARHGAP29 Mutation Is Associated with Abnormal Oral Epithelial Adhesions. J Dent Res. 2017 Oct;96(11):1298-1305
• All: 2 reference(s)