Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Lyin mutation
(0 available);
any
Sh2d1a mutation
(10 available)
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immune system
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• Il2-activated NK cells show less ability to kill some types of CD48+ target cells in vitro
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hematopoietic system
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• Il2-activated NK cells show less ability to kill some types of CD48+ target cells in vitro
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Lyin mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
|
hematopoietic system
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• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
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• deficiency present at all ages
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• levels were consistently lower than normal
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immune system
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• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
|
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• deficiency present at all ages
|
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• levels were consistently lower than normal
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• although response to gammaherpesvirus-68 function was similar to wild-type in that there was no observed mortality and morbidity and acute viral infections were cleared, severe and persistent inflammatory responses were found in lungs and liver that were much slower to resolve
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Allelic
Composition |
Sh2d1atm1Lyin/Y
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Genetic
Background |
involves: 129S2/SvPas * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Lyin mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
|
hematopoietic system
 |
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
|
|
|
• deficiency present at all ages
|
|
|
• levels were consistently lower than normal
|
immune system
|
|
• CD8+ T cell numbers are significantly increased relative to controls after gammaherpesvirus-68 infections
|
|
|
• deficiency present at all ages
|
|
|
• levels were consistently lower than normal
|
|
|
• although response to gammaherpesvirus-68 function was similar to wild-type in that there was no observed mortality and morbidity and acute viral infections were cleared, severe and persistent inflammatory responses were found in lungs and liver that were much slower to resolve
|
Analysis Tools