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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		HpnHlb320
heart, lung and blood 320
MGI:3575149
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		HpnHlb320/HpnHlb320 C57BL/6J-HpnHlb320/J MGI:5441019
hm2
 		HpnHlb320/HpnHlb320 involves: C57BL/6J * C57L/J MGI:5441023
ht3
 		HpnHlb320/Hpn+ involves: C57BL/6J * C57L/J MGI:5441024
ot4
 		HpnHlb320/? C57BL/6J-HpnHlb320/J MGI:3575254


Genotype
MGI:5441019
hm1
Allelic
Composition		 HpnHlb320/HpnHlb320
Genetic
Background		 C57BL/6J-HpnHlb320/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

hearing/vestibular/ear
impaired hearing ( J:187708 )
• hearing loss in males




Genotype
MGI:5441023
hm2
Allelic
Composition		 HpnHlb320/HpnHlb320
Genetic
Background		 involves: C57BL/6J * C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:187708 )
• significantly lower than in wild-type or heterozygous mice

growth/size/body
decreased body size ( J:187708 )




Genotype
MGI:5441024
ht3
Allelic
Composition		 HpnHlb320/Hpn+
Genetic
Background		 involves: C57BL/6J * C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:187708 )
• intermediate reduction compared to wild-type and homozygous mice




Genotype
MGI:3575254
ot4
Allelic
Composition		 HpnHlb320/?
Genetic
Background		 C57BL/6J-HpnHlb320/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:82961 )
• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted plasma HDL of 26 mg/dl
increased circulating cholesterol level ( J:82961 )
• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted plasma total cholesterol of 35 mg/dl




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory