About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		HpnHlb320
heart, lung and blood 320
MGI:3575149
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		HpnHlb320/HpnHlb320 C57BL/6J-HpnHlb320/J MGI:5441019
hm2
 		HpnHlb320/HpnHlb320 involves: C57BL/6J * C57L/J MGI:5441023
ht3
 		HpnHlb320/Hpn+ involves: C57BL/6J * C57L/J MGI:5441024
ot4
 		HpnHlb320/? C57BL/6J-HpnHlb320/J MGI:3575254


Genotype
MGI:5441019
hm1
Allelic
Composition		 HpnHlb320/HpnHlb320
Genetic
Background		 C57BL/6J-HpnHlb320/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism

hearing/vestibular/ear
impaired hearing ( J:187708 )
• hearing loss in males




Genotype
MGI:5441023
hm2
Allelic
Composition		 HpnHlb320/HpnHlb320
Genetic
Background		 involves: C57BL/6J * C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:187708 )
• significantly lower than in wild-type or heterozygous mice

growth/size/body
decreased body size ( J:187708 )




Genotype
MGI:5441024
ht3
Allelic
Composition		 HpnHlb320/Hpn+
Genetic
Background		 involves: C57BL/6J * C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:187708 )
• intermediate reduction compared to wild-type and homozygous mice




Genotype
MGI:3575254
ot4
Allelic
Composition		 HpnHlb320/?
Genetic
Background		 C57BL/6J-HpnHlb320/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
HpnHlb320 mutation (1 available); any Hpn mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating HDL cholesterol level ( J:82961 )
• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted plasma HDL of 26 mg/dl
increased circulating cholesterol level ( J:82961 )
• at 8 weeks of age, consuming chow, this animal had a 4 hour fasted plasma total cholesterol of 35 mg/dl




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory