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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hspa1btm1Jss
targeted mutation 1, Jeong-Sun Seo
MGI:3575001
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hspa1btm1Jss/Hspa1btm1Jss involves: C57BL/6 MGI:3576230


Genotype
MGI:3576230
hm1
Allelic
Composition		 Hspa1btm1Jss/Hspa1btm1Jss
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa1btm1Jss mutation (0 available); any Hspa1b mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to oxidative stress ( J:97232 )
• osmotic stress reduced cell viability of embryonic fibroblasts isolated from homozygous mice
increased kidney apoptosis ( J:97232 )
• when osmotic stress was applied in vivo, homozygous mice exhibited increased apoptosis in the renal medulla

renal/urinary system
increased kidney apoptosis ( J:97232 )
• when osmotic stress was applied in vivo, homozygous mice exhibited increased apoptosis in the renal medulla




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory