Phenotypes associated with this allele

• Allele Symbol: Chmp2b⁺
• Allele Name: wild type
• Allele ID: MGI:3574932
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Chmp2b^em1(IMPC)Mbp/Chmp2b^+	C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd	MGI:6370392
ht2	Chmp2b^tm1.1Hiok/Chmp2b^+	involves: C57BL/6J	MGI:7284279

Genotype
MGI:6370392

ht1

• Allelic Composition: Chmp2b^em1(IMPC)Mbp/Chmp2b⁺
• Genetic Background: C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Chmp2b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal freezing behavior ( J:211773 )

♀

IMPC - UCD

cardiovascular system

decreased heart rate ( J:211773 )

♀

IMPC - UCD

prolonged RR interval ( J:211773 )

♀

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged spleen ( J:211773 )

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

abnormal uterus morphology ( J:211773 )

♀

IMPC - UCD

hydrometra ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:7284279

ht2

• Allelic Composition: Chmp2b^tm1.1Hiok/Chmp2b⁺
• Genetic Background: involves: C57BL/6J

nervous system

abnormal cerebral cortex morphology ( J:308471 )

• cytoplasmic ubiquitinated NUP62 aggregates in frontal association cortex and M2 motor cortex from age 6 months and dysgranular retrosplenial cortex from age 6 months

abnormal frontal lobe morphology ( J:308471 )

• cytoplasmic ubiquitinated NUP62 aggregates in frontal association cortex from age 6 months

abnormal primary motor cortex morphology ( J:308471 )

• cytoplasmic ubiquitinated NUP62 aggregates in M2 motor cortex from age 6 months

cellular

abnormal endoplasmic reticulum morphology ( J:308471 )

• ER expansion in cortical neurons

abnormal cell cycle checkpoint function ( J:308471 )

• delayed or arrested G1/S transition in embryonic neural stem cells (NSCs) from cerebral cortex of E15 embryos

cellular necrosis ( J:308471 )

• early-stage transcriptional repression-induced atypical cell death (TRIAD) necrosis of neurons in cerebral cortex from ages 1 to 12 months, peaking at 3 months

behavior/neurological

impaired spatial learning ( J:308471 )

• increased latency to find platform in Morris water maze test from age 1 months

increased anxiety-related response ( J:308471 )

• increased distance traveled in open field test and less time spent in light in light-dark box test from age 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
frontotemporal dementia		DOID:9255		J:308471