Phenotypes associated with this allele
Allelic
Composition |
Hgftm1Jmw/Hgftm1Jmw
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation
(1 available);
any
Hgf mutation
(55 available)
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liver/biliary system
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• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)
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cellular
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• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation
(1 available);
any
Hgf mutation
(55 available)
Tg(Pax2-cre)1Akg mutation
(2 available)
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hearing/vestibular/ear
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• reduction in future strial intermediate cells
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pigmentation
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• reduction in future strial intermediate cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hgftm1Jmw mutation
(1 available);
any
Hgf mutation
(55 available)
Tg(Mx1-cre)29-4Her mutation
(0 available)
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liver/biliary system
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• liver regenerative capacity (assessed by BrdU incorporation) is decreased 1.5-fold following pI:pC treatment and CCl4 administration, compared to controls receiving PBS and CCl4 treatment
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• 6-8 week old mice treated with poly I:C to induce cre expression, treated with CCl4 to induce liver injury show decreased liver regenerative capacity (~1.5-fold decrease)
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cellular
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• liver regenerative capacity (assessed by BrdU incorporation) is decreased 1.5-fold following pI:pC treatment and CCl4 administration, compared to controls receiving PBS and CCl4 treatment
|
liver/biliary system
|
|
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)
|
|
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• 6-8 week-old mice treated with adeno-cre to delete HGF receiving CCl4 to induce liver injury and GdCl3 either 24 hours prior to and with cre treatment or 10 days post-cre treatment to reduce Kuppfler cell numbers show significantly reduced liver regeneration capacity
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cellular
|
|
• with CCl4 treatment, adenocre administration, and GdCl3 10 days post-cre treatment to reduce Kuppfler cells, a major reduction in hepatocyte DNA synthesis is observed (1.8-2-fold reduction in BrdU incorporation)
|
Analysis Tools