Phenotypes associated with this allele

• Allele Symbol: Hrk^tm1Nnz
• Allele Name: targeted mutation 1, Gabriel Nunez
• Allele ID: MGI:3574591
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hrk^tm1Nnz/Hrk^tm1Nnz	involves: 129 * C57BL/6J	MGI:3574815

Genotype
MGI:3574815

hm1

• Allelic Composition: Hrk^tm1Nnz/Hrk^tm1Nnz
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased neuron apoptosis ( J:96893 )

• 45% of superior cervical ganglion neurons underwent apoptosis compared to about 65% of wildtype by 36 hours of nerve growth factor deprivation

• 10% reduction in the number of hypoglossal nucleus neurons (compared to 50% in wildtype) 35 days after transection of the hypoglossal nerve, indicating protection from cell death

abnormal superior cervical ganglion morphology ( J:96893 )

• delayed neuronal cell death after nerve growth factor withdrawal

• 45% of superior cervical ganglion neurons underwent apoptosis compared to about 65% of wildtype by 36 hours of nerve growth factor deprivation

• increased preservation of mitochondrial membrane potential in superior cervical ganglion neurons after nerve growth factor deprivation compared to wildtype neurons

abnormal hypoglossal nerve morphology ( J:96893 )

• 10% reduction in the number of hypoglossal nucleus neurons (compared to 50% in wildtype) 35 days after transection of the hypoglossal nerve, indicating protection from cell death

cellular

decreased neuron apoptosis ( J:96893 )

• 45% of superior cervical ganglion neurons underwent apoptosis compared to about 65% of wildtype by 36 hours of nerve growth factor deprivation

• 10% reduction in the number of hypoglossal nucleus neurons (compared to 50% in wildtype) 35 days after transection of the hypoglossal nerve, indicating protection from cell death