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Targeted Allele Detail
Symbol: Hrktm1Nnz
Name: harakiri, BCL2 interacting protein (contains only BH3 domain); targeted mutation 1, Gabriel Nunez
MGI ID: MGI:3574591
Synonyms: DP5-
Gene: Hrk  Location: Chr5:118307829-118327543 bp, + strand  Genetic Position: Chr5, 58.16 cM, cytoband F
Alliance: Hrktm1Nnz page
Germline Transmission:  Earliest citation of germline transmission: J:96893
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe single coding exon was replaced with a neomycin resistance cassette. RT-PCR of mutant brain, spleen, thymus, bone marrow and liver samples demonstrated the lack of transcript. (J:96893)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hrk Mutation:  0 strains or lines available
Original:  J:96893 Imaizumi K, et al., Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. J Neurosci. 2004 Apr 14;24(15):3721-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory