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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		IghdeltaD
delta D, Rudolf Jaenisch
MGI:3574367
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		IghdeltaD/IghdeltaD involves: C57BL/6 * DBA/2 MGI:3575925
ht2
 		IghdeltaD/Igh+ involves: C57BL/6 * DBA/2 MGI:3575926
ht3
 		IghdeltaD/Ightm11.1Cgn involves: C57BL/6 * DBA/2 MGI:3687971


Genotype
MGI:3575925
hm1
Allelic
Composition		 IghdeltaD/IghdeltaD
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:95981 )
• B cell progenitors blocked at the pro- to pre-B cell transition
decreased B cell number ( J:95981 )
• reduced numbers of B cells, about 34 fold at 5 weeks and 7 fold at 6 months of age
decreased follicular B cell number ( J:95981 )
• follicular B cells more reduced than marginal zone B cells
increased marginal zone B cell number ( J:95981 )
• marginal zone B cells increase 7 fold between 5 and 25 weeks of age as opposed to a 3 fold increase in controls
increased IgA level ( J:95981 )
• IgA levels were 2X those found in heterozygotes
decreased IgG1 level ( J:95981 )
• IgG1 levels were reduced 5 fold from levels in heterozygotes

immune system
arrested B cell differentiation ( J:95981 )
• B cell progenitors blocked at the pro- to pre-B cell transition
decreased B cell number ( J:95981 )
• reduced numbers of B cells, about 34 fold at 5 weeks and 7 fold at 6 months of age
decreased follicular B cell number ( J:95981 )
• follicular B cells more reduced than marginal zone B cells
increased marginal zone B cell number ( J:95981 )
• marginal zone B cells increase 7 fold between 5 and 25 weeks of age as opposed to a 3 fold increase in controls
increased IgA level ( J:95981 )
• IgA levels were 2X those found in heterozygotes
decreased IgG1 level ( J:95981 )
• IgG1 levels were reduced 5 fold from levels in heterozygotes




Genotype
MGI:3575926
ht2
Allelic
Composition		 IghdeltaD/Igh+
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:95981 )
• few, if any, B cells formed using mutant allele
decreased immunoglobulin level ( J:95981 )
• little, if any, antibody formed using the mutant allele

immune system
decreased B cell number ( J:95981 )
• few, if any, B cells formed using mutant allele
decreased immunoglobulin level ( J:95981 )
• little, if any, antibody formed using the mutant allele




Genotype
MGI:3687971
ht3
Allelic
Composition		 IghdeltaD/Ightm11.1Cgn
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
IghdeltaD mutation (0 available); any Igh mutation (43 available)
Ightm11.1Cgn mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:113434 )
• analysis shows that VH replacement contributes more or is more frequent direct VH to DH joining in determining IgH chain repertoire

hematopoietic system
abnormal B cell differentiation ( J:113434 )
• analysis shows that VH replacement contributes more or is more frequent direct VH to DH joining in determining IgH chain repertoire




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory