Analysis Tools
mortality/aging
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• embryos died before E7.5
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Allele Symbol Allele Name Allele ID |
Stxbp3tm1Jpes targeted mutation 1, Jeffrey Pessin MGI:3573931 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos died before E7.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• glucose-stimulated insulin secretion was significantly decreased in islets
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• glucose-stimulated insulin secretion was significantly decreased in islets
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• after 10 weeks on a high-fat diet, had significantly increased fasting blood glucose indicating susceptibility for developing hyperglycemia however serum triglyceride levels were normal
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• severely impaired glucose tolerance after 5 weeks on a high-fat diet, however food consumption, body weight gain, and tissue weight redistribution on the high-fat diet did not differ from wildtype and had normal glucose tolerance on a standard diet
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• significantly decreased insulin sensitivity in an insulin tolerance test
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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