Stxbp3^tm1Jpes
Targeted Allele Detail

Summary

• Symbol: Stxbp3^tm1Jpes
• Name: syntaxin binding protein 3; targeted mutation 1, Jeffrey Pessin
• MGI ID: MGI:3573931
• Synonyms: Munc18c^-, Stxbp3a^tm1Dct, Stxbp3^tm1Jepn
• Gene: Stxbp3 Location: Chr3:108700496-108747818 bp, - strand Genetic Position: Chr3, 47.73 cM, cytoband F3
• Alliance: Stxbp3^tm1Jpes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96731
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ATG-coding exon was replaced by a neo in reverse orientation to transcription. Optical density scanning showed that protein was reduced by ~50% in tissues of heterozygous mice. (J:96731)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Stxbp3 Mutation: 22 strains or lines available

References

• Original: J:96731 Oh E, et al., Munc18c heterozygous knockout mice display increased susceptibility for severe glucose intolerance. Diabetes. 2005 Mar;54(3):638-47
• All: 5 reference(s)