Phenotypes associated with this allele

• Allele Symbol: Olig3^tm1Tre
• Allele Name: targeted mutation 1, Mathias Treier
• Allele ID: MGI:3573868
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Olig3^tm1Tre/Olig3^tm1Tre	involves: 129P2/OlaHsd	MGI:3574083
ht2	Olig3^tm1Tre/Olig3^tm2(cre/ERT2)Cbm	Not Specified	MGI:3833734
cx3	Lbx1^tm1Cbm/Lbx1^tm1Cbm Olig3^tm1Tre/Olig3^tm1Tre	involves: 129P2/OlaHsd	MGI:3574085

Genotype
MGI:3574083

hm1

• Allelic Composition: Olig3^tm1Tre/Olig3^tm1Tre
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:96749 )

• the number of neurons generated in the dorsal alar plate was reduced at E11.5

abnormal neuronal migration ( J:96749 )

• differences in the migration of class A neurons were apparent at E11 and more pronounced by E12.5, as observed by ectopically located neurons in the lateral positions of the dorsal spinal cord and at sites typically occupied by class B neurons

abnormal neuron specification ( J:96749 )

• a reduction of the numbers of dI1 neurons in the dorsal spinal cord, the alar plate, and no generation of dI2 and dI3 neurons, instead ectopic neurons of the class B (dI4) appear in the dorsal alar plate indicating that class A (dI2 and dI3) neurons were not correctly specified and assume the fate of class B neuronal subtype

cellular

abnormal neuron differentiation ( J:96749 )

• the number of neurons generated in the dorsal alar plate was reduced at E11.5

abnormal neuronal migration ( J:96749 )

• differences in the migration of class A neurons were apparent at E11 and more pronounced by E12.5, as observed by ectopically located neurons in the lateral positions of the dorsal spinal cord and at sites typically occupied by class B neurons

Genotype
MGI:3833734

ht2

• Allelic Composition: Olig3^tm1Tre/Olig3^{tm2(cre/ERT2)Cbm}
• Genetic Background: Not Specified

nervous system

abnormal neuron differentiation ( J:143526 )

• the nucleus of the solitary tract did not form

• precerebellar nuclei, such as the inferior olivary nucleus, were absent or small

abnormal neuron specification ( J:143526 )

• the fate of dA4 neurons is not correctly determined, resulting in the absence of climbing finer neurons of the inferior olivary nucleus

• the fate of dA3 neurons was not correctly determined, resulting in the absence of the nucleus of the solitary tract and the area postrema

• ectopic Lbx1+ neurons appeared in the alar plate

cellular

abnormal neuron differentiation ( J:143526 )

• the nucleus of the solitary tract did not form

• precerebellar nuclei, such as the inferior olivary nucleus, were absent or small

Genotype
MGI:3574085

cx3

• Allelic Composition: Lbx1^tm1Cbm/Lbx1^tm1Cbm; Olig3^tm1Tre/Olig3^tm1Tre
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal neuron differentiation ( J:96749 )

• dI3 neurons in the dorsal spinal cord, the alar plate, were not generated, although dI1 and dI2 neurons were formed

cellular

abnormal neuron differentiation ( J:96749 )

• dI3 neurons in the dorsal spinal cord, the alar plate, were not generated, although dI1 and dI2 neurons were formed