All Phenotypes Tg(Il1rn)1Dih MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ldlr^tm1Her/Ldlr^tm1Her Tg(Il1rn)1Dih/Tg(Il1rn)1Dih	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3574185
tg2	Tg(Il1rn)1Dih/Tg(Il1rn)1Dih	involves: C57BL/6 * CBA	MGI:3574186
tg3	Tg(Il1rn)1Dih/0	involves: C57BL/6 * CBA	MGI:3574188

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)
Tg(Il1rn)1Dih mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:76336 )

• when fed high-cholesterol, high-fat diet containing cholate for 4 weeks, 40% decrease in atherosclerosis lesion size when compared to homozygous single Ldlr^tm1Her mutant mice

homeostasis/metabolism

increased circulating cholesterol level ( J:76336 )

• 40% increase in total plasma cholesterol (non-HDL) when fed cholesterol-fat enriched Western diet for 10 weeks; slight increase in total plasma cholesterol level when fed high-cholesterol, high-fat diet containing cholate for 4 weeks

increased circulating triglyceride level ( J:76336 )

• 40% increase in total plasma triglyceride level when fed cholesterol-fat enriched Western diet for 10 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hypercholesterolemia		DOID:13810	OMIM:143890	J:76336

Allelic Composition	Tg(Il1rn)1Dih/Tg(Il1rn)1Dih
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Il1rn)1Dih mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased circulating interleukin-1 level ( J:36387 )

• serum IL-1 levels are higher following lipopolysaccharide (LPS) endotoxin challenge

decreased susceptibility to endotoxin shock ( J:36387 )

• less susceptible to lipopolysaccharide (LPS) endotoxin challenge

increased susceptibility to bacterial infection ( J:36387 )

• more susceptible to experimental Listeria monocytogenes infection

homeostasis/metabolism

increased circulating interleukin-1 level ( J:36387 )

• serum IL-1 levels are higher following lipopolysaccharide (LPS) endotoxin challenge

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal angiogenesis ( J:88605 )

• reduced angiogenesis observed in stromal keratitis caused by herpes simplex virus (HSV) ocular infection, reduced vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR-2) levels

immune system

decreased circulating interleukin-6 level ( J:88605 )

• reduced IL-6 levels in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection

decreased circulating serum amyloid protein level ( J:61600 )

• 30% decrease in serum amyloid P levels after subcutaneous turpentine administration

decreased inflammatory response ( J:88605 )

• reduced polymorphonuclear leukocyte infiltration in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection

decreased susceptibility to endotoxin shock ( J:36387 )

• less susceptible to lipopolysaccharide (LPS) endotoxin challenge, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous

increased susceptibility to bacterial infection ( J:36387 )

• more susceptible to experimental Listeria monocytogenes infection, hemizygotes exhibit an intermediate phenotype when compared to wild-type and homozygous

decreased susceptibility to Herpesvirales infection ( J:88605 )

• severity of stromal keratitis caused by herpes simplex virus (HSV) ocular infection is diminished

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:88605 )

• reduced IL-6 levels in response to stromal keratitis caused by herpes simplex virus (HSV) ocular infection

decreased circulating serum amyloid protein level ( J:61600 )

• 30% decrease in serum amyloid P levels after subcutaneous turpentine administration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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