Phenotypes associated with this allele

• Allele Symbol: Tg(Gcg-TAg)25Ddr
• Allele Name: transgene insertion 25, Daniel J Drucker
• Allele ID: MGI:3531421
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Gcg-TAg)25Ddr/?	involves: CD-1	MGI:5829432

Genotype
MGI:5829432

tg1

• Allelic Composition: Tg(Gcg-TAg)25Ddr/?
• Genetic Background: involves: CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:91490 )

• mice die 4-12 weeks after birth

neoplasm

increased colon tumor incidence ( J:101537 )

• progressive epithelial cell proliferation in the large bowl from 3 days of age that progresses to colonic tumors

• colonic tumors retain features of endocrine differentiation but have smaller secretory granules

increased large intestine adenocarcinoma incidence ( J:91490 , J:101537 )

• enteroendocrine cell hyperplasia in the large bowel progresses to invasive and metastasizing plurihormonal endocrine carcinoma that is evident by 4 weeks of age (J:91490)

• by 4 weeks of age, the large bowel contains foci of invasive endocrine carcinoma that penetrate through the muscular wall of the bowl (J:91490)

increased pancreas tumor incidence ( J:91490 , J:101537 )

• large hyperplastic islets are seen by 4 weeks of age which progresses to tumor formation from 4 to 8 weeks of age (J:91490)

• mice develop pancreatic endocrine tumors showing large nodules composed of pleomorphic tumor cells in the pancreas of 11 and 12 week old mice (J:101537)

• pancreatic tumor cells display some morphological features of neurons, including neurofilament and tyrosine hydroxylase immunoreactivity and elongated cell processes with preferential storage of secretory granules in the processes and lack features of A cells and contain very little glucagon (J:101537)

increased metastatic potential ( J:91490 , J:101537 )

• occasionally, lymph node metastases involving pericolonic and para-aortic lymph nodes, are seen (J:91490)

• 12 of 38 mice with colonic tumors show metastases in pericolonic and para-aortic lymph nodes (J:101537)

digestive/alimentary system

abnormal intestinal enteroendocrine cell morphology ( J:91490 )

• focal areas of enteroendocrine cell hyperplasia in the large bowel

abnormal large intestine morphology ( J:101537 )

• large bowel is thickened from the cecum to the rectum

distended cecum ( J:91490 , J:101537 )

• dilatation of the cecum by 4-8 weeks of age, associated with a firm thickened segment of the large bowel extending from the cecum to the rectum (J:91490)

increased colon tumor incidence ( J:101537 )

• progressive epithelial cell proliferation in the large bowl from 3 days of age that progresses to colonic tumors

• colonic tumors retain features of endocrine differentiation but have smaller secretory granules

increased large intestine adenocarcinoma incidence ( J:91490 , J:101537 )

• enteroendocrine cell hyperplasia in the large bowel progresses to invasive and metastasizing plurihormonal endocrine carcinoma that is evident by 4 weeks of age (J:91490)

• by 4 weeks of age, the large bowel contains foci of invasive endocrine carcinoma that penetrate through the muscular wall of the bowl (J:91490)

abnormal intestinal epithelium physiology ( J:91490 )

• progressive development of epithelial cell proliferation in the lamina propria of the large bowel starting from day 1 after birth

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:91490 , J:101537 )

• pancreas contains irregular islets with large cells harboring pleomorphic nuclei and clear cytoplasm at the periphery at 1-3 months of age (J:91490)

• by 4 weeks of age, many pancreatic islets are large and display disrupted architecture (J:91490)

• islets display disrupted architecture by 4 weeks of age (J:101537)

• pancreas of young mice (3, 7, and 14 days of age) contains islets with occasional single pleomorphic cells at the periphery; these cells increase in number with age (J:101537)

enlarged pancreatic islets ( J:101537 )

• islets are large by 4 weeks of age

pancreatic islet hyperplasia ( J:91490 )

• large hyperplastic islets are seen by 4 weeks of age which progresses to tumor formation from 4 to 8 weeks of age

increased pancreas tumor incidence ( J:91490 , J:101537 )

• large hyperplastic islets are seen by 4 weeks of age which progresses to tumor formation from 4 to 8 weeks of age (J:91490)

• mice develop pancreatic endocrine tumors showing large nodules composed of pleomorphic tumor cells in the pancreas of 11 and 12 week old mice (J:101537)

• pancreatic tumor cells display some morphological features of neurons, including neurofilament and tyrosine hydroxylase immunoreactivity and elongated cell processes with preferential storage of secretory granules in the processes and lack features of A cells and contain very little glucagon (J:101537)

growth/size/body

weight loss ( J:91490 )

• smaller body size by 3 weeks of age and mice weigh 40-50% less than controls by 4-6 weeks of age

cachexia ( J:91490 )

• mice become gradually wasted