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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sle16C57BL/6
C57BL/6
MGI:3531335
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		C1qatm1Mjw/C1qatm1Mjw
Sle16129S6/SvEvTac/Sle16C57BL/6 		involves: 129S/SvEv * 129X1/Sv * C57BL/6 MGI:3701668
cx2
 		Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6 		involves: C57BL/6 * FVB/N MGI:5427949


Genotype
MGI:3701668
cx1
Allelic
Composition		 C1qatm1Mjw/C1qatm1Mjw
Sle16129S6/SvEvTac/Sle16C57BL/6
Genetic
Background		 involves: 129S/SvEv * 129X1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qatm1Mjw mutation (1 available); any C1qa mutation (20 available)
Sle16129S6/SvEvTac mutation (0 available); any Sle16 mutation (0 available)
Sle16C57BL/6 mutation (0 available); any Sle16 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system




Genotype
MGI:5427949
cx2
Allelic
Composition		 Fcgr2btm1.2Jsv/Fcgr2btm1.2Jsv
Sle16C57BL/6/Sle16C57BL/6
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr2btm1.2Jsv mutation (1 available); any Fcgr2b mutation (44 available)
Sle16C57BL/6 mutation (0 available); any Sle16 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
albuminuria ( J:179175 )
• mild
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
abnormal renal glomerulus morphology ( J:179175 )
• at 8 months, mice develop mild nonlethal glomerular damage compared with wild-type mice

immune system
immune system phenotype ( J:179175 )
N
• unlike Fcgr2btm1Ttk homozygotes, mice do not develop high anti-nuclear antibodies titers spontaneously or increased spleen weight
abnormal adaptive immunity ( J:179175 )
• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes
kidney inflammation ( J:179175 )
• in a nephrotoxic nephritis model
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

skeleton
increased susceptibility to induced arthritis ( J:179175 )
• collagen or K/BXN serum-induced
• however, lower incidence and delayed onset compared to in Fcgr2btm1Ttk homozygotes

homeostasis/metabolism
abnormal glomerular capillary thrombosis ( J:179175 )
• in a nephrotoxic nephritis model
albuminuria ( J:179175 )
• mild

hematopoietic system
increased immunoglobulin level ( J:179175 )
• kidney IgG and C3 depositions in a nephrotoxic nephritis model




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory