All Phenotypes Sle16<C57BL/6> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	C1qa^tm1Mjw/C1qa^tm1Mjw Sle16^{129S6/SvEvTac}/Sle16^C57BL/6	involves: 129S/SvEv * 129X1/Sv * C57BL/6	MGI:3701668
cx2	Fcgr2b^tm1.2Jsv/Fcgr2b^tm1.2Jsv Sle16^C57BL/6/Sle16^C57BL/6	involves: C57BL/6 * FVB/N	MGI:5427949

Allelic Composition	C1qa^tm1Mjw/C1qa^tm1Mjw Sle16^{129S6/SvEvTac}/Sle16^C57BL/6
Genetic Background	involves: 129S/SvEv * 129X1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1qa^tm1Mjw mutation (1 available); any C1qa mutation (22 available)
Sle16^{129S6/SvEvTac} mutation (0 available); any Sle16 mutation (0 available)
Sle16^C57BL/6 mutation (0 available); any Sle16 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to systemic lupus erythematosus ( J:118645 )

increased anti-nuclear antigen antibody level ( J:118645 )

increased anti-chromatin antibody level ( J:118645 )

increased anti-double stranded DNA antibody level ( J:118645 )

increased anti-single stranded DNA antibody level ( J:118645 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

albuminuria ( J:179175 )

• mild

kidney inflammation ( J:179175 )

• in a nephrotoxic nephritis model

• however, lower incidence and delayed onset compared to in Fcgr2b^tm1Ttk homozygotes

abnormal renal glomerulus morphology ( J:179175 )

• at 8 months, mice develop mild nonlethal glomerular damage compared with wild-type mice

immune system

immune system phenotype ( J:179175 )

N	• unlike Fcgr2b^tm1Ttk homozygotes, mice do not develop high anti-nuclear antibodies titers spontaneously or increased spleen weight

abnormal adaptive immunity ( J:179175 )

• mice exhibit increased antibody response after immunization, in mast cell-mediated cutaneous anaphylaxis, and in phagocytosis of immune complex (IC) by macrophages compared with control mice

increased immunoglobulin level ( J:179175 )

• kidney IgG and C3 depositions in a nephrotoxic nephritis model

increased susceptibility to induced arthritis ( J:179175 )

• collagen or K/BXN serum-induced

• however, lower incidence and delayed onset compared to in Fcgr2b^tm1Ttk homozygotes

kidney inflammation ( J:179175 )

• in a nephrotoxic nephritis model

• however, lower incidence and delayed onset compared to in Fcgr2b^tm1Ttk homozygotes

skeleton

increased susceptibility to induced arthritis ( J:179175 )

• collagen or K/BXN serum-induced

• however, lower incidence and delayed onset compared to in Fcgr2b^tm1Ttk homozygotes

homeostasis/metabolism

abnormal glomerular capillary thrombosis ( J:179175 )

• in a nephrotoxic nephritis model

albuminuria ( J:179175 )

• mild

hematopoietic system

increased immunoglobulin level ( J:179175 )

• kidney IgG and C3 depositions in a nephrotoxic nephritis model

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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