Analysis Tools
craniofacial
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• cell numbers are increased in the maxilla, but no increase in mitotic cells or change in apoptosis is seen
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• palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
• palatine bones are displaced medially
• palatine bones are small and constrained but roughly normal in shape
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• mice exhibit enlarged maxillary processes as early as E9.0 and by E9.5, the maxillary domain is larger, indicating maxillary hyperplasia
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• palatal primordia are evident at the appropriate stage but are displaced medially compared to controls and do not extend ventrally at E13.5
• at E14.5, the palatal condensations do not extend and appear as one contiguous domain by E16
• however, a recognizable palate can form despite an initial failure of shelf outgrowth and the majority of midfacial bones are present and ossifying
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• mice show expanded mesenchyme within the oral cavity
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• palatal narrowing and palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
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• mice appear to have a cleft secondary palate but frontal sections show that palatal shelves are not clefted and instead, palatine bones show the classic inverted-V shape typical of high arched palate, commonly referred to as pseudo-cleft
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digestive/alimentary system
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• palatal primordia are evident at the appropriate stage but are displaced medially compared to controls and do not extend ventrally at E13.5
• at E14.5, the palatal condensations do not extend and appear as one contiguous domain by E16
• however, a recognizable palate can form despite an initial failure of shelf outgrowth and the majority of midfacial bones are present and ossifying
|
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• palatal narrowing and palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
|
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• mice appear to have a cleft secondary palate but frontal sections show that palatal shelves are not clefted and instead, palatine bones show the classic inverted-V shape typical of high arched palate, commonly referred to as pseudo-cleft
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growth/size/body
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• cell numbers are increased in the maxilla, but no increase in mitotic cells or change in apoptosis is seen
|
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• palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
• palatine bones are displaced medially
• palatine bones are small and constrained but roughly normal in shape
|
|
• palatal primordia are evident at the appropriate stage but are displaced medially compared to controls and do not extend ventrally at E13.5
• at E14.5, the palatal condensations do not extend and appear as one contiguous domain by E16
• however, a recognizable palate can form despite an initial failure of shelf outgrowth and the majority of midfacial bones are present and ossifying
|
|
• mice show expanded mesenchyme within the oral cavity
|
|
• palatal narrowing and palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
|
|
• mice appear to have a cleft secondary palate but frontal sections show that palatal shelves are not clefted and instead, palatine bones show the classic inverted-V shape typical of high arched palate, commonly referred to as pseudo-cleft
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limbs/digits/tail
polydactyly
(
J:198631
)
nervous system
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• brain overgrowth is seen at E12.5
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respiratory system
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• upper airway anomalies
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skeleton
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• cell numbers are increased in the maxilla, but no increase in mitotic cells or change in apoptosis is seen
|
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• palatine bone defects are seen throughout the anterior-posterior extent of the secondary palate
• palatine bones are displaced medially
• palatine bones are small and constrained but roughly normal in shape
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• mice show complete synostosis of the coronal sutures
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vision/eye
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• eye defects are seen at E12.5
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ciliopathy | DOID:0060340 | J:198631 | ||
