About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MrasGt(OST108223)Lex
gene trap OST108223, Lexicon Genetics
MGI:3530902
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		MrasGt(OST108223)Lex/MrasGt(OST108223)Lex B6;129S5-MrasGt(OST108223)Lex/Ieg MGI:5428683
hm2
 		MrasGt(OST108223)Lex/MrasGt(OST108223)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3701854


Genotype
MGI:5428683
hm1
Allelic
Composition		 MrasGt(OST108223)Lex/MrasGt(OST108223)Lex
Genetic
Background		 B6;129S5-MrasGt(OST108223)Lex/Ieg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MrasGt(OST108223)Lex mutation (2 available); any Mras mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:82809 )
• a decreased mean percentage of peripheral blood B cells is seen in the homozygous mutant mice compared to controls

immune system
decreased B cell number ( J:82809 )
• a decreased mean percentage of peripheral blood B cells is seen in the homozygous mutant mice compared to controls




Genotype
MGI:3701854
hm2
Allelic
Composition		 MrasGt(OST108223)Lex/MrasGt(OST108223)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MrasGt(OST108223)Lex mutation (2 available); any Mras mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:112961 )
• mice are not morphologically different from wild-type mice and have normal brain morphology and function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory