Mras^{Gt(OST108223)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Mras^{Gt(OST108223)Lex}
• Name: muscle and microspikes RAS; gene trap OST108223, Lexicon Genetics
• MGI ID: MGI:3530902
• Synonyms: Mras^-, Mras^{Gt(neo)623Lex}
• Gene: Mras Location: Chr9:99267473-99319434 bp, - strand Genetic Position: Chr9, 51.63 cM
• Alliance: Mras^{Gt(OST108223)Lex} page

Mutation origin

• Mutant Cell Line: OST108223
• Germline Transmission: Earliest citation of germline transmission: J:112961
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector VICT20 inserted into intron 1. Transcription was most likely inactivated by the splicing of exon 1 to the splice acceptor site within the retroviral sequence. Northern blot confirmed absence of transcripts in mutant brains and livers. (J:112961)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST108223	CG528630 ; (MGI Seq Detail)	3' RACE	Chr9:99271833-99293627 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  133 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mras Mutation: 98 strains or lines available

References

• Original: J:112961 Nunez Rodriguez N, et al., Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling. Mol Cell Biol. 2006 Oct;26(19):7145-54
• All: 6 reference(s)